Signaling Molecules Last updated Dec 14, 2021 Save as PDF Zn and inhibitor citric acid binding to carboxypeptidase A (3KGQ) Abscisic acid bound to the Abscisic Acid Receptor (PYL2) (pdbid - 3KDI) Page ID74881 ( \newcommand{\kernel}{\mathrm{null}\,}\) Abscisic acid bound to the Abscisic Acid Receptor (PYL2) (pdbid - 3KDI)Activated insulin receptor tyrosine kinase domain in complex with peptide substrate and ATP analog (1IR3)Active human apoptosome with procaspase-9 (5JUY)Active Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain (7T6F)Adenylyl cyclase activator Gsalpha with GTP-gamma-S (1azt)AKT (Protein Kinase B) bound to a novel allosteric inhibitor is shown below (3o96)AKT Pleckstrin Homology (PH) domain bound to inositol (1,3,4,5)-tetrakisphosphate (1unq)Aligned structures of human c-Src (2SRC) and Erk2 (2Y9Q)Alignment of inactive AKT (3o96 with bound allosteric inhibitor) and active AKT(3cqw with bound substate)Alignment of MEK 1 (4U7Z) - a MAPKK - and ERK2 (5NHJ) a MAPKAlignment of the PKA kinase domain (1J3H A chain) and the EGFR kinase domain (2GS6)AlphaFold-predicted model of human Z-DNA-Binding Protein 1 (ZBP1), (Q9H171AlphaFold computational model of full length human PTEN (Uniprot P60484)Amphiphilic anchoring peptide AKAP-IS from AKAP binding to the docking and dimerization (D/D) domain of the RIIalpha regulatory subunit of PKA (2IZX)Auxin bound in the hydrophobic pocket of its receptor TIR1 ubiquitin ligase (2P1Q)Auxin bound to its receptor TIR1 ubiquitin ligase (2P1Q)Bacterial rhodopsin (1C3W)Bovine cyclin A (1VIN) Calcineurin (PP2B) complex bound to a peptide from the Na+ /H+ -exchanger 1 (6NUC)catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor (1ATP)CBD-bound full-length rat TRPV2 in nanodiscs (6U88)cGMP-dependent protein kinase 2 -AlphaFold Model (2Q13237)Class A GPCR Cannabinoid Receptor-GiComplex Structures (6KPF) Complex of Abscisic acid-bound PYL1 and the Protein Phosphatase 2C ABI1 (pdbid 3kdj)Complex of Human FasL and Its Decoy Fas Receptor DcR (4MSV)Cryo-EM Structure of calcium sensing receptor in complex gamma-glutamyl-valyl-glycine as a kokumi substance γ-glutamyl-valyl-glycine or γ-EVG (9J7I)Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA (1BF5)Crystal structure of the beta2 adrenergic receptor-Gs protein complex (3SN6)Diclofenac bound to the cyclooxygenase active site of COX-2 (1PXX)DNA binding domain of arabidopsis thaliana auxin response factor 1 (ARF1) in complex with protomor-like sequence ER7 (4LDX)E. Coli Transcriptional activator CadC One Component System - AlphaFold Model (P23890)EGFR kinase domain in complex with an ATP analog-peptide conjugate (2GS6)Eicosapentaenoic acid bound GPR120-Gi complex (8ID9) Epidermal Growth Factor Receptor - EGF Dimer (3NJP)Estrogen receptor DNA-binding domain bound to DNA (1HCQ)Fas-Tumor necrosis factor receptor superfamily member 6 AlphaFold model (P25445)Fragment of the nitrate/nitrite sensor histidine kinase NarQ (mutant R50K) in the symmetric holo state (IJI)Full human estrogen receptor computational model (P03372, AlphaFold)Gibberellin(GA3)-gibberellin receptor GID1L1-DELLA complex (2ZSH)GRB2-SH2 domain in complex with a high affinity phosphopeptide KPFpYVNVEF (1BMB)GRB2 N-terminal SH3 domain complexed with a ten-residue proline-rich peptide derived from SOS (1GBQ)G alpha (q)-phospholipase C-beta 3 structure (4GNK)Headpiece of integrin αIIbβ3 in the headpiece extended and open conformation (3FCU)Histidine kinase 4 - Cytokinin receptor 1 (CRE) from Arabidopsis thaliana (AlphaFold model) - Domain organization (Q9C5U0)Histidine kinase 4 - Cytokinin receptor 1 (CRE) from Arabidopsis thaliana (AlphaFold model) - PFAM Domain organization (Q9C5U0)Holo-calmodulin with 4 bound Ca2+ ions (1CLL)Human AMPK (a2b2g1) in complex with a small molecule activator SC4 (6B2E)Human Apaf-1 AlphaFold model (O14727)Human atrial natriuretic peptide receptor1 AlphaFold predicted model (P16066)Human Ca2+ Calmodulin- Dependent Kinase II Holoenzyme (3SOA)Human Cas 9 AlphaFold model (P55211)Human CB1 in complex with agonist AM11542 (5XRA)Human CDK-activating kinase (CAK) - Cyclin-dependent kinase (CDK) 7 with cyclin H and MAT1 (6xbz)Human cyclin-dependent kinase 2 with a bound ATP (1HCK)Human full-length heteromeric α1-β3-γ2L GABA(A)R in complex with diazepam (Valium) and GABA (6HUP)Human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with picrotoxin and GABA (6huj)Human KRAS G12C covalently bound to AMG 510 (6OIM)Human low molecular weight protein tyrosine phosphatase bound to sulfate (1xww)Human mTORC1 complex (5FLC)Human neuronal nitric oxide synthase - Alpha Fold prediction V2Human neuronal nitric oxide synthase predicted by AlphaFold (P29475)Human prostaglandin E receptor EP3 bound to prostaglandin E2 (6AK3)Human Protein Phosphatase 1 Active Site Residues (4mov)Human Protein Tyrosine Phosphatase 1B (1-301) in complex with the inhibitor OTA (5K9W)Human Rack1 - a PKC Scaffolding Protein (4AOW)Human sodium channel 1.2-beta2-KIIIA ternary complex (6J8E)Human sodium channel Nav1.2-beta2-KIIIA ternary complex highlighting just the DEKA selectivity filter and the IFM and its receptor inactivation gate F1651, L1660 and N1662 (6J8E)Human soluble guanylate cyclase in the riociguat and NO-bound state (7D9R)Human synaptic alpha1beta3gamma2 GABA(A)R in complex with Ro15-4513 (7QNE)Human TRPV1 with capsaicin at 48 degrees Celsius in an open state (7LPE)Human two pore domain temperature-sensitive potassium ion channel TREK2 (K2P10.1) (4BW5)Human tyrosine-protein kinase C-Src in complex with AMP-PNP (2SRC)Inactive Serum and Glucocorticoid- Regulated Kinase 1 in Complex with AMP-PNP (2R5T)Inactive SGK 1 and AMP-PNP highlighting activation and catalytic features (2R5T)Inhibitory protein SOCS1 in complex with JAK1 kinase domain (6C7Y)Leucine-bound Sestrin2 complex (5DJ4)Ligand binding domain of human estrogen receptor ERα bound to the antagonist tamoxifen (3ERT)Mammalian tactile channel PIEZO2 (6KG7)Membrane adenylyl cyclase bound to an activated stimulatory G protein 6R3QMembrane domain of E. coli histidine kinase receptor KdpD (2KSF)Mouse mechanosensitive Piezo1 channel (5Z10)Mouse temperature sensitive K2P2.1 (TREK-1) potassium channels (6W84)mTOR - LST8 complex with bound AGS, a nonhydrolyzable ATP analog (4JSP)Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrazolo-pyrimidinone 5 (6MDB)Nonpolar environment of eicosapentaenoic acid bound to GPR120 (8ID9)Odorant Binding Protein 1 from Anopheles gambiae (AgamOBP1) with DEET (N,N-Diethyl-meta-toluamide) and PEG 216 (3N7H)Phospho-CDK2 Cyclin A in complex with a peptide containing both the substrate and recruitment sites of CDC6(2CCI)Phosphorylated cyclin-dependent kinase 2 bound to cyclin A (1JST)Phosphotyrosine peptide bound to the SH2 domain of Fer tyrosine kinase (6KC4)Phytochrome (Deinococcus) Pfr form in the Photoactivated State (5C5K)PKC (alpha)-C2 domain complexed with Ca ions and IP3 (3GPE)Predicted structure of human integrin alpha-1 (AlphaFold - P56199)Protein Kinase C beta II (3PFQ)Protein phosphatase 1 (PP1) bound to the muscle glycogen-targeting subunit (Gm) and microcystin (6DNO)Protein phosphatase 2A core enzyme (catalytic and regulatory subunit) bound to okadaic acidRas-GAP complex (1WQ1)Ras and SOS (a GEF) complex (1bkd) Second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA (3EYI)Semaglutide-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in Complex with Gs protein (7KI0)Semaglutide in GLP-1R-bound conformation (7KI0)Single EGFR kinase domain showing N and C termnial lobes in complex with an ATP analog-peptide conjugate (2GS6)Single subunit of human Ca2+ Calmodulin- Dependent Kinase II Holoenzyme (3SOA)Structure of α6β1 integrin in complex with laminin-511 (7CEC)S aureus Universal stress protein (USP) domain of KdpD histidine kinase in complex with 2nd messenger c-di-AMP (7JI4)Taste receptor type 1 member 2 (TAS1R2) AlphaFold model (uniprot Q8TE23)Template for hovering iCn3DsTernary complex of the plant hormone abscisic acid, PYL1 (receptor) and ABI1 (phospholipase 2C) (3KDJTRPM8 ion channel in complex with the menthol analog WS-12 and PI(4,5)P2 (6NR2)two Fas death domains bound to two FADD death domain (3EZQ)