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- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/Unit_IV_-_Special_Topics/28%3A_Biosignaling_-_Capstone_Volume_I/28.19%3A_Signal_Transduction_-__TemperatureThis page describes the mechanisms of temperature sensing and thermoregulation in mammals, exploring the roles of different ion channels, particularly TRP and TREK channels, in detecting thermal stimu...This page describes the mechanisms of temperature sensing and thermoregulation in mammals, exploring the roles of different ion channels, particularly TRP and TREK channels, in detecting thermal stimuli. It delves into how these channels contribute to the sensation of heat, cold, and thermal pain, with TREK channels playing a key role in moderating thermoreceptor activity by hyperpolarizing cells and TRP channels depolarizing them to increase excitability.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/01%3A_Unit_I-_Structure_and_Catalysis/05%3A_Protein_Function/5.03%3A_B._Other_Allosteric_ProteinsThis page covers the intricacies of allosterism in biochemistry, focusing on myoglobin, hemoglobin, and various enzymes, including lactate dehydrogenase and phosphofructokinases. It discusses structur...This page covers the intricacies of allosterism in biochemistry, focusing on myoglobin, hemoglobin, and various enzymes, including lactate dehydrogenase and phosphofructokinases. It discusses structural transformations in viral enzymes and the significance of Lenacapavir as an HIV drug. The text details the kinetic behaviors of enzymes and the influence of ligand concentrations on activity.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/01%3A_Unit_I-_Structure_and_Catalysis/06%3A_Enzyme_Activity/6.03%3A_Kinetics_with_EnzymesThis page provides an in-depth exploration of enzyme kinetics, focusing on learning goals such as understanding kinetic principles, the Michaelis-Menten framework, and enzyme-catalyzed reactions. It c...This page provides an in-depth exploration of enzyme kinetics, focusing on learning goals such as understanding kinetic principles, the Michaelis-Menten framework, and enzyme-catalyzed reactions. It covers concepts like reaction rates, the significance of Vmax and Km, catalytic efficiency, and the use of various plots to interpret kinetic data.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/02%3A_Unit_II-_Bioenergetics_and_Metabolism/14%3A_Principles_of_Metabolic_Regulation/14.04%3A_Concentration_Control_and_Elasticity_CoefficientsThis page aims to educate biochemistry students on key aspects of metabolic control analysis by focusing on two important concepts: the concentration control coefficient and the elasticity coefficient...This page aims to educate biochemistry students on key aspects of metabolic control analysis by focusing on two important concepts: the concentration control coefficient and the elasticity coefficient. It covers the definitions and significance of these coefficients, providing insights into how enzyme activity affects metabolite concentrations and reaction rates.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/01%3A_Unit_I-_Structure_and_Catalysis/06%3A_Enzyme_Activity/6.05A%3A_Enzyme_Reaction_Mechanisms_-_Arrow_PushingThis page outlines learning goals for biochemistry students on enzyme catalysis, covering mechanisms and roles of enzymes, particularly focusing on serine proteases like chymotrypsin and their catalyt...This page outlines learning goals for biochemistry students on enzyme catalysis, covering mechanisms and roles of enzymes, particularly focusing on serine proteases like chymotrypsin and their catalytic strategies. It details the function of magnesium in phosphate transfer, the classification of proteases, and the mechanisms of specific enzymes like carboxypeptidase A and lysozyme.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/02%3A_Unit_II-_Bioenergetics_and_Metabolism/14%3A_Principles_of_Metabolic_Regulation/14.02%3A_Basic_Principles_of_Metabolic_Control_Analysis_(MCA)The page outlines learning goals and key concepts for understanding enzyme kinetics, metabolic control analysis (MCA), and steady-state dynamics in biochemical pathways. It emphasizes the importance o...The page outlines learning goals and key concepts for understanding enzyme kinetics, metabolic control analysis (MCA), and steady-state dynamics in biochemical pathways. It emphasizes the importance of studying enzymes in both isolated and integrated settings, the contrast between steady state and equilibrium, and the use of computational modeling tools like Vcell to simulate metabolic pathways.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/01%3A_Unit_I-_Structure_and_Catalysis/06%3A_Enzyme_Activity/6.02%3A_Kinetics_without_EnzymesThis page provides a comprehensive overview of chemical kinetics, focusing on both non-enzymatic and enzymatic reactions. It explores concepts like reaction rates, rate laws, and half-lives, and expla...This page provides a comprehensive overview of chemical kinetics, focusing on both non-enzymatic and enzymatic reactions. It explores concepts like reaction rates, rate laws, and half-lives, and explains how to write and interpret differential and integrated rate equations. The text discusses first and second-order reactions, their kinetics, and how to graphically represent and interpret them.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/Unit_IV_-_Special_Topics/32%3A_Biochemistry_and_Climate_Change/32.12%3A__Part_3_-_A_Warmer_World%3A_Temperature_Effects_On_ProteinsThis page covers various learning goals related to biochemistry, particularly focusing on protein thermal stability, denaturation mechanisms, heat-shock responses, adaptations in thermophiles, enzyme ...This page covers various learning goals related to biochemistry, particularly focusing on protein thermal stability, denaturation mechanisms, heat-shock responses, adaptations in thermophiles, enzyme kinetics, and experimental methods for studying thermal effects. It emphasizes the biological importance of these concepts in the context of climate change and their applications in biotechnology and pharmaceuticals.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/02%3A_Unit_II-_Bioenergetics_and_Metabolism/14%3A_Principles_of_Metabolic_Regulation/14.5%3A_Metabolism_and_Signaling%3A__The_Steady_State_Adaptation_and_HomeostasisThe page covers key biochemistry concepts, specifically focusing on enzyme kinetics, metabolic pathways, and homeostasis. It introduces hyperbolic and sigmoidal binding interactions, their implication...The page covers key biochemistry concepts, specifically focusing on enzyme kinetics, metabolic pathways, and homeostasis. It introduces hyperbolic and sigmoidal binding interactions, their implication on metabolic control, and the role of enzyme kinetics in maintaining cellular homeostasis. It also discusses adaptive motifs in metabolic regulation, including feedback systems and their contribution to metabolic stability.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/02%3A_Unit_II-_Bioenergetics_and_Metabolism/14%3A_Principles_of_Metabolic_Regulation/14.03%3A_The_Flux_Control_CoefficientThis page discusses metabolic control analysis (MCA), with a focus on the Flux Control Coefficient, used to assess enzyme contributions to metabolic flux regulation. It highlights key concepts, such a...This page discusses metabolic control analysis (MCA), with a focus on the Flux Control Coefficient, used to assess enzyme contributions to metabolic flux regulation. It highlights key concepts, such as the Summation Theorem and flux distribution across enzymes, debunking the idea of a singular "rate-limiting" enzyme.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/01%3A_Unit_I-_Structure_and_Catalysis/03%3A_Amino_Acids_Peptides_and_Proteins/3.3%3A_Protein_PurificationThe page describes the key concepts and steps involved in protein purification and characterizes different techniques used in the purification process. It outlines various chromatographic methods such...The page describes the key concepts and steps involved in protein purification and characterizes different techniques used in the purification process. It outlines various chromatographic methods such as ion exchange, size-exclusion, hydrophobic interaction, and affinity chromatography. Additionally, it explains electrophoresis methods like SDS-PAGE and 2D electrophoresis.
