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- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/02%3A_Unit_II-_Bioenergetics_and_Metabolism/19%3A_Oxidative_Phosphorylation/19.03%3A_Regulation_of_Oxidative_PhosphorylationThe page discusses key concepts in biochemistry related to oxidative phosphorylation including the roles of AMP, ADP, and ATP in regulating metabolic pathways, the coupling of electron transport to pr...The page discusses key concepts in biochemistry related to oxidative phosphorylation including the roles of AMP, ADP, and ATP in regulating metabolic pathways, the coupling of electron transport to proton translocation, and the consequences of uncoupling. It emphasizes the integration of metabolic regulation across various pathways and how mitochondria communicate with the nucleus.
- https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/04%3A_Cell_Metabolism/4.05%3A_Cellular_RespirationThis page discusses cellular respiration, detailing its conversion of glucose into ATP through glycolysis and mitochondrial processes, including the citric acid cycle and electron transport chain. It ...This page discusses cellular respiration, detailing its conversion of glucose into ATP through glycolysis and mitochondrial processes, including the citric acid cycle and electron transport chain. It highlights mitochondrial DNA (mtDNA) mutations as a cause of diseases, influenced by heteroplasmy. Mitochondrial Replacement Techniques are being studied to prevent the transmission of defective mtDNA from mothers.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/02%3A_Unit_II-_Bioenergetics_and_Metabolism/13%3A_Glycolysis_Gluconeogenesis_and_the_Pentose_Phosphate_Pathway/13.03%3A_GluconeogenesisThe page provides an in-depth exploration of gluconeogenesis, a metabolic process that generates glucose from non-carbohydrate sources. Key topics include the pathway's role in maintaining blood gluco...The page provides an in-depth exploration of gluconeogenesis, a metabolic process that generates glucose from non-carbohydrate sources. Key topics include the pathway's role in maintaining blood glucose levels, especially during fasting or low-carbohydrate intake, its occurrence primarily in the liver and kidneys, and the detailed enzymatic steps involved.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/02%3A_Unit_II-_Bioenergetics_and_Metabolism/18%3A_Nitrogen_-_Amino_Acid_Catabolism/18.04%3A_An_overview_of_amino_acid_metabolism_and_the_role_of_CofactorsThis page presents a comprehensive breakdown of amino acid metabolism, covering the pathways involved in amino acid catabolism, the categorization of amino acids as glucogenic or ketogenic, the role o...This page presents a comprehensive breakdown of amino acid metabolism, covering the pathways involved in amino acid catabolism, the categorization of amino acids as glucogenic or ketogenic, the role of key cofactors in these metabolic processes, and the involvement of amino acids in one-carbon metabolism through cycles like folate and methionine.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/Unit_IV_-_Special_Topics/29%3A_Integration_of_Mammalian_Metabolism_-_Capstone_Volume_II/29.10%3A_Ethanol_metabolism-_The_good_the_bad_and_the_uglyThe article explores ethanol's role as a commercial commodity and its medical and social implications. Ethanol is metabolized in the body to acetaldehyde and acetate, impacting cellular energy and bra...The article explores ethanol's role as a commercial commodity and its medical and social implications. Ethanol is metabolized in the body to acetaldehyde and acetate, impacting cellular energy and brain function. Chronic alcohol consumption leads to metabolic disorders such as fatty liver and brain neurotransmitter imbalances. Acute ethanol intake disrupts glucose and amino acid metabolism in the brain.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/Unit_IV_-_Special_Topics/29%3A_Integration_of_Mammalian_Metabolism_-_Capstone_Volume_II/29.04%3A_Skeletal_Muscle_Regulates_MetabolismSkeletal muscle plays key roles in physical movement, energy balance, and protein metabolism. It is crucial for glucose uptake and amino acid storage, influencing energy and protein metabolism across ...Skeletal muscle plays key roles in physical movement, energy balance, and protein metabolism. It is crucial for glucose uptake and amino acid storage, influencing energy and protein metabolism across the body. Conditions like sarcopenia and cachexia result from muscle loss due to aging, diseases, and metabolic shifts, leading to negative health and economic consequences.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/Unit_IV_-_Special_Topics/29%3A_Integration_of_Mammalian_Metabolism_-_Capstone_Volume_II/29.02%3A__Regulation_of_glucose_metabolism_from_a_liver-centric_perspectiveThis article explores the regulation of glucose metabolism from a liver-centric perspective. The liver plays a vital role in maintaining glucose homeostasis through processes such as glycogenesis, gly...This article explores the regulation of glucose metabolism from a liver-centric perspective. The liver plays a vital role in maintaining glucose homeostasis through processes such as glycogenesis, glycogenolysis, glycolysis, and gluconeogenesis. Acute and chronic regulation of the enzymes involved is crucial for these processes. Transcription factors such as SREBP-1c and ChREBP are vital in controlling glucose metabolism, especially in glycolysis and gluconeogenesis paths.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/Unit_IV_-_Special_Topics/29%3A_Integration_of_Mammalian_Metabolism_-_Capstone_Volume_II/29.03%3A_Emerging_role_of_the_brain_in_the_homeostatic_regulation_of_energy_and_glucose_metabolismThe article discusses the central role of the brain, particularly the hypothalamus, in regulating energy and glucose metabolism. It integrates inputs from peripheral signals like nutrients and hormone...The article discusses the central role of the brain, particularly the hypothalamus, in regulating energy and glucose metabolism. It integrates inputs from peripheral signals like nutrients and hormones, modulating metabolism-related activities such as food intake, energy expenditure, and insulin secretion. Disturbances in this regulation can lead to obesity and type 2 diabetes. Understanding the neural pathways involved could aid in developing treatments for these conditions.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/Unit_IV_-_Special_Topics/32%3A_Biochemistry_and_Climate_Change/32.10%3A__Part_2_-_Biohydrogen_-_HydrogenasesThis page outlines learning goals focused on hydrogenases, enzymes pivotal in biohydrogen metabolism. It emphasizes understanding hydrogenases' roles, structure-function relationships, catalytic mecha...This page outlines learning goals focused on hydrogenases, enzymes pivotal in biohydrogen metabolism. It emphasizes understanding hydrogenases' roles, structure-function relationships, catalytic mechanisms, and physiological contexts. Additionally, it explores environmental and industrial potential, factors affecting activity, and strategies for genetic and metabolic engineering to optimize hydrogenase performance.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/02%3A_Unit_II-_Bioenergetics_and_Metabolism/16%3A_The_Citric_Acid_Cycle/16.04%3A_Variants_of_the_Citric_Acid_CycleThe page provides a detailed overview of various metabolic shunts and bypass mechanisms related to the citric acid cycle. It covers the glyoxylate shunt, allowing organisms like plants, bacteria, and ...The page provides a detailed overview of various metabolic shunts and bypass mechanisms related to the citric acid cycle. It covers the glyoxylate shunt, allowing organisms like plants, bacteria, and fungi to use acetate effectively for gluconeogenesis. The GABA shunt integrates nitrogen metabolism with energy production, significant for stress responses and neural function.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/02%3A_Unit_II-_Bioenergetics_and_Metabolism/17%3A_Fatty_Acid_Catabolism/17.01%3A_Digestion_Mobilization_and_Transport_of_FatsThe page covers the structure, classification, synthesis, metabolism, and physiological roles of lipoproteins, including their importance in energy metabolism and cholesterol homeostasis. It explores ...The page covers the structure, classification, synthesis, metabolism, and physiological roles of lipoproteins, including their importance in energy metabolism and cholesterol homeostasis. It explores the roles of different types of adipose tissues (white and brown) along with metabolic pathways implicating lipportotein interactions with cellular receptors.
