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Biology LibreTexts

9. Transposition of DNA

The final method of changing the DNA in a genome that we will consider is transposition, which is the movement of DNA from one location to another. Segments of DNA with this ability to move are called transposable elements. Transposable elements were formerly thought to be found only in a few species, but now they are recognized as components of the genomes of virtually all species.

References

  • Shapiro, J. A. (editor) (1983) Mobile Genetic Elements (Academic Press, Inc., New York).
  • Fedoroff, N. and Botstein, D. (1992) The Dynamic Genome: Barbara McClintock’s Ideas in the Century of Genetics (Cold Spring Harbor Press, Plainview, NY).
  • McClintock, B. (1952) Chromosome organization and genic expression. Cold Spring Harbor Symposium on Quantitative Biology 16: 13-47.
  • Fedoroff, N., Wessler, S., and Shure, M. (1983) Isolation of the transposable maize controlling elements Ac and Ds. Cell 35:235-242.Boeke, J.D., Garfinkel, D.J., Styles, C.A., and Fink G.R. (1985) Ty elements transpose through an RNA intermediate. Cell 40:491-500
  • Kazazian, H.H. Jr, Wong, C., Youssoufian, H., Scott, A.F., Phillips, D.G., and Antonarakis, S.E. (1988) Haemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man. Nature 332:164-166.
  • International Human Genome Sequencing Consortium (2001) Initial sequencing and analysis of the human genome. Nature 409: 860-921. The material from pages 879-889 covers human repeats and transposable elements.