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24: Hypersensitivites

Last updated

Jan 22, 2025
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- 23.E: Adaptive Immunity II (Exercises)
- 24.1: Type I Hypersensitivities

Ying Liu
City College of San Francisco

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An allergic reaction is an immune response to a type of antigen called an allergen. Allergens can be found in many different items, from peanuts and insect stings to latex and some drugs. Unlike other kinds of antigens, allergens are not necessarily associated with pathogenic microbes, and many allergens provoke no immune response at all in most people.

Allergic responses vary in severity. Some are mild and localized, like hay fever or hives, but others can result in systemic, life-threatening reactions. Anaphylaxis, for example, is a rapidly developing allergic reaction that can cause a dangerous drop in blood pressure and severe swelling of the throat that may close off the airway.

Allergies are just one example of how the immune system—the system normally responsible for preventing disease—can actually cause or mediate disease symptoms. In this chapter, we will further explore allergies and other disorders of the immune system, including hypersensitivity reactions, autoimmune diseases, transplant rejection, and diseases associated with immunodeficiency.

Photo of a bee on a flower. Photo of an EpiPen. — Figure $\PageIndex{1}$ : Bee stings and other allergens can cause life-threatening, systemic allergic reactions. Sensitive individuals may need to carry an epinephrine auto-injector (e.g., EpiPen) in case of a sting. A bee-sting allergy is an example of an immune response that is harmful to the host rather than protective; epinephrine counteracts the severe drop in blood pressure that can result from the immune response. (credit right: modification of work by Carol Bleistine)

24.1: Type I Hypersensitivities
An allergy is an adaptive immune response, sometimes life-threatening, to an allergen. Hypersensitivity reactions are classified by their immune mechanism.
24.2: Type II Hypersensitivities
An allergy is an adaptive immune response, sometimes life-threatening, to an allergen. Hypersensitivity reactions are classified by their immune mechanism.
24.3: Type III Hypersensitivities
An allergy is an adaptive immune response, sometimes life-threatening, to an allergen. Hypersensitivity reactions are classified by their immune mechanism.
24.4: Type IV Hypersensitivities
An allergy is an adaptive immune response, sometimes life-threatening, to an allergen. Hypersensitivity reactions are classified by their immune mechanism.
24.5: Hypersensitivity Pneumonitis and Summary
An allergy is an adaptive immune response, sometimes life-threatening, to an allergen. Hypersensitivity reactions are classified by their immune mechanism.
24.6: Diagnosis and Treatment of Hypersensitivities
An allergy is an adaptive immune response, sometimes life-threatening, to an allergen. Hypersensitivity reactions are classified by their immune mechanism.
24.E: Diseases of the Immune System (Exercises)

Thumbnail: Allergens in plant pollen, shown here in a colorized electron micrograph, may trigger allergic rhinitis or hay fever in sensitive individuals. (Public Domain/modified from original; Dartmouth Electron Microscope Facility, Dartmouth College via Wikimedia Commons).

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