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Arthur Sikora Lipid rafts

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    108136
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    Exercise \(\PageIndex{1}\)

    What kinds of lipids are found in a eukaryotic cell membrane under normal conditions?

    Here is a Hint if you need one

    Answer

    Glycerophospholipids, sphingolipids, sterols and fatty acids. 

     

    Authored by Arthur Sikora.  Last update:  6/5/2023

    Date of origin

    Introduction

    Lipid rafts are formed and dissipated over time. They are regions where specific lipids are enriched, frequently resulting in protein aggregation as well

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    Lipids being removed and added to a membrane

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    Figure \(\PageIndex{x}\) is an interactive iCn3D model of [INSERT DESCRIPTIVE TEXT - often a modified version of the title from the actual PDB page 4Q7Q

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    NIH_NCBI_iCn3D_Banner.svgFigure \(\PageIndex{6}\): [INSERT THE PDB TITLE as above (INSERT PDB CODE)]. Click the image for a popup or use this external link: [https://structure.ncbi.nlm.nih.gov/i...PGDeccDmTH3Nq8].  (Copyright; author via source).  iCn3D model made by Arthur Sikora


    VCellLogo.png MODEL

    No inhibition (left) and Uncompetitive Inhibition (right)

    NoInhi_CompInhib_MM_I_RxDiag.png

    Note that the Vcell reaction diagram is the same as for competitive and uncompetive inhibition.  It doesn't explicitly show that the mixed inhibitor binds to both free and substrate-bound enzymes.  Those interactions are addressed in the mathematical equations for mixed inhibition.

    Initial values No Inhibition

    No_UNCOMP_inhibInitCond.png

    Initial values With Uncompetitive Inhibitor

    MIXED_inhibInitCond.png

    I is fixed for each simulation (as it is not converted to a product) but can be changed in the simulation below.

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    Interactive Element

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    Time course model made using Virtual Cell (Vcell), The Center for Cell Analysis & Modeling, at UConn Health.  Funded by NIH/NIGMS (R24 GM137787); Web simulation software (miniSidewinder) from Bartholomew Jardine and Herbert M. Sauro, University of Washington.  Funded by NIH/NIGMS (RO1-GM123032-04)


     

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    Arthur Sikora Lipid rafts is shared under a not declared license and was authored, remixed, and/or curated by LibreTexts.

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