Arthur Sikora Lipid rafts

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Exercise \(\PageIndex{1}\)

What kinds of lipids are found in a eukaryotic cell membrane under normal conditions?

Here is a Hint if you need one

Answer

Glycerophospholipids, sphingolipids, sterols and fatty acids.

Authored by Arthur Sikora. Last update: 6/5/2023

Date of origin

Introduction

Lipid rafts are formed and dissipated over time. They are regions where specific lipids are enriched, frequently resulting in protein aggregation as well

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Lipids being removed and added to a membrane

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MODEL

No inhibition (left) and Uncompetitive Inhibition (right)

Note that the Vcell reaction diagram is the same as for competitive and uncompetive inhibition. It doesn't explicitly show that the mixed inhibitor binds to both free and substrate-bound enzymes. Those interactions are addressed in the mathematical equations for mixed inhibition.

Initial values No Inhibition

Initial values With Uncompetitive Inhibitor

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Time course model made using Virtual Cell (Vcell), The Center for Cell Analysis & Modeling, at UConn Health. Funded by NIH/NIGMS (R24 GM137787); Web simulation software (miniSidewinder) from Bartholomew Jardine and Herbert M. Sauro, University of Washington. Funded by NIH/NIGMS (RO1-GM123032-04)

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