29.01B: A New View of the Citric Acid Cycle - Its Origin and Its Role in Health and Disease

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Under Construction from 4/11/24 - ????

Biological cells have a daunting task. They must carry out 1000s of different chemical reactions required to carry out cell function. These reactions can include opposing goals such as energy production and energy storage, macromolecule degradation and synthesis, and breakdown and synthesis of small molecules. All of these reactions are catalyzed by proteins and RNAs enzymes whose activities must be regulated, again through chemical reactions, to avoid a futile and energy wasting scenario of having opposing pathways functioning simultaneously in a cell.

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Glycolysis;

flux_into_glycolysis_june2021 (Original).mp4

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This animation shows carbon flux from glucose (6-carbon (C) metabolite) through the catabolic pathway of glycolysis where glucose is broken down into pyruvate (3C metabolite) in the cytosol. Note the energy consumed and released during this process.

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