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- https://bio.libretexts.org/Workbench/Biochem_Remix_Acevedo/05%3A_Protein_Function/5.01%3A__Binding_-_The_First_Step_Toward_Protein_FunctionJust as we used the +/- 2 pH rule in determining at a glance the charge state of an acid, you need to be able to determine the extent of binding (how much of M is bound with L) given their relative co...Just as we used the +/- 2 pH rule in determining at a glance the charge state of an acid, you need to be able to determine the extent of binding (how much of M is bound with L) given their relative concentrations and the K D . The usual situation is that [M 0 ] is << [L 0 ].
- https://bio.libretexts.org/Workbench/Biochem_Remix_Acevedo/08%3A_Nucleotides_and_Nucleic_Acids/8.03%3A_Nucleic_Acids_-_Comparison_of_DNA_and_RNANow that we have an understanding of the structures of DNA and the structures and various functions of RNA, we can now more fully explore how their chemical similarities and difference contribute to d...Now that we have an understanding of the structures of DNA and the structures and various functions of RNA, we can now more fully explore how their chemical similarities and difference contribute to different functions.
- https://bio.libretexts.org/Workbench/Biochem_Remix_Acevedo/06%3A_Enzyme_Activity/6.05%3A_Enzyme_and_Protein_RegulationThe reaction of proteins with a variety of free radicals and reactive oxygen species (ROS) leads to oxidative protein modifications such as the formation of protein hydroperoxides, hydroxylation of ar...The reaction of proteins with a variety of free radicals and reactive oxygen species (ROS) leads to oxidative protein modifications such as the formation of protein hydroperoxides, hydroxylation of aromatic groups and aliphatic amino acid side chains, oxidation of sulfhydryl groups, oxidation of methionine residues, conversion of some amino acid residues into carbonyl groups, cleavage of the polypeptide chain, and formation of cross-linking bonds.
- https://bio.libretexts.org/Workbench/Biochem_Remix_Acevedo/04%3A_The_Three-Dimensional_Structure_of_Proteins/4.06%3A_Protein_Aggregates_-_Amyloids_Prions_and_Intracellular_GranulesThe Figure \PageIndex8 shows a comparison of the secondary structures of the native conformation of the light chain and those found in the two different fibrillar forms (A and B) of the amyloid ...The Figure \PageIndex8 shows a comparison of the secondary structures of the native conformation of the light chain and those found in the two different fibrillar forms (A and B) of the amyloid fibrils (panel a). The protein found in the plaques, called the PrP sc (the scrapie form of the normal protein) is insoluble in aqueous solution, protease-resistant, and has a high beta sheet content (43%) and lower alpha helix content (30%) than the normal version of the protein PrPc.
- https://bio.libretexts.org/Workbench/Biochem_Remix_Acevedo/05%3A_Protein_Function/5.02%3A_Oxygen-Binding_Proteins_and_AllosterismThe proximal His (coordinated to the Fe 2 + ) is pulled toward the heme, which causes the F helix to shift, causing a change in the FG corner (the sequence separating the F and G helices) at the alpha...The proximal His (coordinated to the Fe 2 + ) is pulled toward the heme, which causes the F helix to shift, causing a change in the FG corner (the sequence separating the F and G helices) at the alpha-beta interface as well as the C and G helices at the interface, which all slide past each other to the oxy-or R conformation.
- https://bio.libretexts.org/Workbench/Biochem_Remix_Acevedo/07%3A_Carbohydrates_and_GlycobiologyThumbnail: Cellulose molecular structure (CC BY-SA 3.0 Unported; Pintor4257 via Wikipedia)
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/03%3A_Unit_III-_Information_Pathway/26%3A_Protein_Metabolism/26.02%3A_Protein_SynthesisThe page provides an in-depth overview of the translation process in both prokaryotic and eukaryotic cells. Key learning goals include understanding the central role of translation in gene expression,...The page provides an in-depth overview of the translation process in both prokaryotic and eukaryotic cells. Key learning goals include understanding the central role of translation in gene expression, comprehending the molecular machinery involved, outlining the stages of translation (initiation, elongation, termination), analyzing the energetics and fidelity of protein synthesis, and comparing the translation mechanisms in prokaryotes and eukaryotes.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/Unit_IV_-_Special_Topics/28%3A_Biosignaling_-_Capstone_Volume_I/28.01%3A_General_Features_of_Signal_TransductionThe page provides a comprehensive overview of cell signaling tailored for biochemistry students. It delineates the process of signal transduction, emphasizing the cellular response to external signals...The page provides a comprehensive overview of cell signaling tailored for biochemistry students. It delineates the process of signal transduction, emphasizing the cellular response to external signals and the crucial roles of receptors and second messengers. It discusses the intricacies of logic gates in cellular signaling and the post-translational modifications of proteins.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/Unit_IV_-_Special_Topics/28%3A_Biosignaling_-_Capstone_Volume_I/28.14%3A_Programmed_Cell_DeathThe page provides an in-depth exploration of programmed cell death, focusing particularly on apoptosis, its mechanisms, and its significance in health and disease. It distinguishes apoptosis from othe...The page provides an in-depth exploration of programmed cell death, focusing particularly on apoptosis, its mechanisms, and its significance in health and disease. It distinguishes apoptosis from other cell death types such as autophagy and necroptosis, outlining apoptosis's intrinsic and extrinsic pathways, including involved proteins like caspases and Bcl-2 family.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/Unit_IV_-_Special_Topics/28%3A_Biosignaling_-_Capstone_Volume_I/28.16%3A_Signaling_in_PlantsThe page provides a comprehensive overview of plant signaling, focusing on key plant hormones such as auxins, cytokinins, gibberellins, abscisic acid, and ethylene. It discusses the synthesis, transpo...The page provides a comprehensive overview of plant signaling, focusing on key plant hormones such as auxins, cytokinins, gibberellins, abscisic acid, and ethylene. It discusses the synthesis, transport, perception, and signal transduction mechanisms of these hormones, highlighting their roles in coordinating plant growth, development, and stress responses.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/02%3A_Unit_II-_Bioenergetics_and_Metabolism/18%3A_Nitrogen_-_Amino_Acid_Catabolism/18.05%3A_Pathways_of_Amino_Acid_DegradationThe page provides an in-depth overview and analysis of amino acid degradation, focusing on pathways and mechanisms involved. It discusses the significance of amino acid catabolism in energy production...The page provides an in-depth overview and analysis of amino acid degradation, focusing on pathways and mechanisms involved. It discusses the significance of amino acid catabolism in energy production, nitrogen balance, regulation, and physiological implications. Key points include distinguishing glucogenic and ketogenic amino acids, integration into central metabolism, enzymes involved, and the regulation of catabolic pathways under varying metabolic states.
