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- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/01%3A_Unit_I-_Structure_and_Catalysis/05%3A_Protein_Function/5.04%3A_B._The_Innate_Immune_System_PAMPs_and_DAMPs_and_InflammationThis page discusses biochemistry learning goals, focusing on protein-ligand interactions and the immune system. Topics include immune response mechanisms, the role of signaling molecules like cGAMP, a...This page discusses biochemistry learning goals, focusing on protein-ligand interactions and the immune system. Topics include immune response mechanisms, the role of signaling molecules like cGAMP, and the importance of mRNA vaccines. It explains pathogen recognition via pattern recognition receptors, inflammasome formation involving proteins like ASC, and the activation of NLRP3 by PAMPS and DAMPS.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/01%3A_Unit_I-_Structure_and_Catalysis/05%3A_Protein_Function/5.06%3A__Binding_-_Conformational_Selections_and_Intrinsically_Disordered_ProteinsThe page outlines learning goals related to protein-ligand interactions, focusing on induced fit and conformational selection, intrinsically disordered proteins (IDPs), and Molecular Recognition Featu...The page outlines learning goals related to protein-ligand interactions, focusing on induced fit and conformational selection, intrinsically disordered proteins (IDPs), and Molecular Recognition Features (MoRFs). It describes models of protein-ligand binding, explores mechanisms of coupling folding and binding, and discusses the role of intrinsic disorder in cellular functions.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/01%3A_Unit_I-_Structure_and_Catalysis/05%3A_Protein_Function/5.02%3A_Techniques_to_Measure_BindingIt is often essential to determine the KD for a ML complex since given that number and the concentrations of M and L in the system, we can then predict if M is bound under physiological conditions. Ag...It is often essential to determine the KD for a ML complex since given that number and the concentrations of M and L in the system, we can then predict if M is bound under physiological conditions. Again, this is important since whether M is bound or free will govern its activity. To determine KD, you need to determine ML and L at equilibrium. How can we differentiate free from bound ligand? The following techniques allow such a differentiation.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/01%3A_Unit_I-_Structure_and_Catalysis/05%3A_Protein_Function/5.04%3A_A._The_Immune_System_-_Antibodies_B-_cells_T-cell_receptors_and_T-cellsThis page provides an overview of the immune system's functionality, detailing the roles of both innate and adaptive immunity, particularly focusing on the mechanisms of B cells and T cells. Key eleme...This page provides an overview of the immune system's functionality, detailing the roles of both innate and adaptive immunity, particularly focusing on the mechanisms of B cells and T cells. Key elements include the structure and diversity of antibodies, significance of immunoglobulin domains, and the dynamics of antibody-antigen interactions.
- https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/15%3A_The_Anatomy_and_Physiology_of_Animals/15.04%3A_Immune_System/15.4B%3A_Antibody-Antigen_BindingThis page explains the role of antibodies produced by B cells in binding to antigens through noncovalent interactions at epitopes. This process can enhance immune responses by forming insoluble comple...This page explains the role of antibodies produced by B cells in binding to antigens through noncovalent interactions at epitopes. This process can enhance immune responses by forming insoluble complexes that facilitate phagocytosis. Antibodies targeting pneumococcal polysaccharides improve the clearance of encapsulated bacteria. The specific binding sites of antibodies, formed by hypervariable regions, are essential for their affinity to epitopes, which is vital for effective immune defense.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/01%3A_Unit_I-_Structure_and_Catalysis/05%3A_Protein_Function/5.01%3A__Binding_-_The_First_Step_Toward_Protein_FunctionThis page outlines learning goals for understanding protein-ligand interactions, including binding thermodynamics, key binding constants like Kd and Ka, and the interpretation of binding curves. It co...This page outlines learning goals for understanding protein-ligand interactions, including binding thermodynamics, key binding constants like Kd and Ka, and the interpretation of binding curves. It compares one-site versus two-site binding models and explores cooperative and allosteric effects. It discusses experimental methods for measuring interactions and relates binding to protein functions in biological contexts.
