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No Product Inhibtion of MAPK cascade

Last updated

Apr 17, 2023
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- No Feedback in MAPK cascade
- Oscillations in MAPK Cascade

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Note: Export Vcell file as omex, SBML (stochastic model); y axis in particles

Species conditions

Species	Initial Conditions	Units
MKKK		Unit_umol
MKKK_P		Unit_umol
MKK		Unit_umol
MKK_P		Unit_umol
MKK_PP		Unit_umol
MAPK		Unit_umol
MAPK_P		Unit_umol
MAPK_PP		Unit_umol

Parameters

Parameter	Value	Units
_F_		Unit_C_mol_1
K1_J0		Unit_nmol_litre_1
V1_J0		Unit_nmol_s_1_litre_1
KK2_J1		Unit_nmol_litre_1
V2_J1		Unit_nmol_s_1_litre_1
KK3_J2		Unit_nmol_litre_1
k3_J2		Unit_s_1
KK4_J3		Unit_nmol_litre_1
k4_J3		Unit_s_1
KK5_J4		Unit_nmol_litre_1
V5_J4		Unit_nmol_s_1_litre_1
V6_J5		Unit_nmol_s_1_litre_1
KK6_J5		Unit_nmol_litre_1
KK7_J6		Unit_nmol_litre_1
k7_J6		Unit_s_1
KK8_J7		Unit_nmol_litre_1
k8_J7		Unit_s_1
V9_J8		Unit_nmol_s_1_litre_1
KK9_J8		Unit_nmol_litre_1
V10_J9		Unit_nmol_s_1_litre_1
KK10_J9		Unit_nmol_litre_1

Simulation ran using VCell & Tellurium and powered by https://run.biosimulations.org

Reference: Kholodenko2000___Ultrasensitivity_and_negative_feedback_bring_oscillations_in_MAPK_cascade

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