SBML_GoldBeter model Calicum ion oscillations
- Page ID
- 106734
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MODEL
Calcium ion oscillation in the cell without oscillations in IP3
Here are the adjustable parameters:
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v0: influx of Ca2+ into the cell, uM/s.
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v1: influx of Ca2+ into the cell from the InsP3 receptor, uM/s.
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beta: saturation function of the receptor for InsP3 , unitless.
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Vm2: maximum rate of Ca2+ pumping into the intracellular InsP3-insensitive store, uM/s.
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Vm3: maximum rate of Ca2+ released from the intracellular store, uM/s;
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K2: Threshold constant for Ca2+ pumping, uM.
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n: Hill function cooperativity coefficient for Ca2+ pumping into the store, unitless.
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m: Hill function cooperativity coefficient for Ca2+ pumping from the store, unitless.
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Ka: threshold constant for activation, uM.
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kf: efflux of cytosolic Ca2+ from the cell, 1/s.
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k: influx of extracellular Ca2+ into the cytosol, 1/s.
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p denotes the degree of cooperativity of the activation process, unitless.
Select Load [model name] below
Select Start to begin the simulation.
Select Plot to change Y axis min/max, then Reset and Play | Select Slider to change which constants are displayed | Select About for software information.
Move the sliders to change the constants and see changes in the displayed graph in real time.
After loading the GoldBeter model, select the 'Start' button below to simulate the model. Adjust the parameter sliders below the plot to see how they affect Ca2+ concentrations (Z, Y). The simulator only displays twelve parameters at a time. To choose others, select the 'Slider' button on the side and chose up to twelve parameters to adjust.
Time course model made using Virtual Cell (Vcell), The Center for Cell Analysis & Modeling, at UConn Health. Funded by NIH/NIGMS (R24 GM137787); Web simulation software (miniSidewinder) from Bartholomew Jardine and Herbert M. Sauro, University of Washington. Funded by NIH/NIGMS (RO1-GM123032-04)