5: Principles of Microbial Metabolism
- Page ID
- 42483
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\(\newcommand{\avec}{\mathbf a}\) \(\newcommand{\bvec}{\mathbf b}\) \(\newcommand{\cvec}{\mathbf c}\) \(\newcommand{\dvec}{\mathbf d}\) \(\newcommand{\dtil}{\widetilde{\mathbf d}}\) \(\newcommand{\evec}{\mathbf e}\) \(\newcommand{\fvec}{\mathbf f}\) \(\newcommand{\nvec}{\mathbf n}\) \(\newcommand{\pvec}{\mathbf p}\) \(\newcommand{\qvec}{\mathbf q}\) \(\newcommand{\svec}{\mathbf s}\) \(\newcommand{\tvec}{\mathbf t}\) \(\newcommand{\uvec}{\mathbf u}\) \(\newcommand{\vvec}{\mathbf v}\) \(\newcommand{\wvec}{\mathbf w}\) \(\newcommand{\xvec}{\mathbf x}\) \(\newcommand{\yvec}{\mathbf y}\) \(\newcommand{\zvec}{\mathbf z}\) \(\newcommand{\rvec}{\mathbf r}\) \(\newcommand{\mvec}{\mathbf m}\) \(\newcommand{\zerovec}{\mathbf 0}\) \(\newcommand{\onevec}{\mathbf 1}\) \(\newcommand{\real}{\mathbb R}\) \(\newcommand{\twovec}[2]{\left[\begin{array}{r}#1 \\ #2 \end{array}\right]}\) \(\newcommand{\ctwovec}[2]{\left[\begin{array}{c}#1 \\ #2 \end{array}\right]}\) \(\newcommand{\threevec}[3]{\left[\begin{array}{r}#1 \\ #2 \\ #3 \end{array}\right]}\) \(\newcommand{\cthreevec}[3]{\left[\begin{array}{c}#1 \\ #2 \\ #3 \end{array}\right]}\) \(\newcommand{\fourvec}[4]{\left[\begin{array}{r}#1 \\ #2 \\ #3 \\ #4 \end{array}\right]}\) \(\newcommand{\cfourvec}[4]{\left[\begin{array}{c}#1 \\ #2 \\ #3 \\ #4 \end{array}\right]}\) \(\newcommand{\fivevec}[5]{\left[\begin{array}{r}#1 \\ #2 \\ #3 \\ #4 \\ #5 \\ \end{array}\right]}\) \(\newcommand{\cfivevec}[5]{\left[\begin{array}{c}#1 \\ #2 \\ #3 \\ #4 \\ #5 \\ \end{array}\right]}\) \(\newcommand{\mattwo}[4]{\left[\begin{array}{rr}#1 \amp #2 \\ #3 \amp #4 \\ \end{array}\right]}\) \(\newcommand{\laspan}[1]{\text{Span}\{#1\}}\) \(\newcommand{\bcal}{\cal B}\) \(\newcommand{\ccal}{\cal C}\) \(\newcommand{\scal}{\cal S}\) \(\newcommand{\wcal}{\cal W}\) \(\newcommand{\ecal}{\cal E}\) \(\newcommand{\coords}[2]{\left\{#1\right\}_{#2}}\) \(\newcommand{\gray}[1]{\color{gray}{#1}}\) \(\newcommand{\lgray}[1]{\color{lightgray}{#1}}\) \(\newcommand{\rank}{\operatorname{rank}}\) \(\newcommand{\row}{\text{Row}}\) \(\newcommand{\col}{\text{Col}}\) \(\renewcommand{\row}{\text{Row}}\) \(\newcommand{\nul}{\text{Nul}}\) \(\newcommand{\var}{\text{Var}}\) \(\newcommand{\corr}{\text{corr}}\) \(\newcommand{\len}[1]{\left|#1\right|}\) \(\newcommand{\bbar}{\overline{\bvec}}\) \(\newcommand{\bhat}{\widehat{\bvec}}\) \(\newcommand{\bperp}{\bvec^\perp}\) \(\newcommand{\xhat}{\widehat{\xvec}}\) \(\newcommand{\vhat}{\widehat{\vvec}}\) \(\newcommand{\uhat}{\widehat{\uvec}}\) \(\newcommand{\what}{\widehat{\wvec}}\) \(\newcommand{\Sighat}{\widehat{\Sigma}}\) \(\newcommand{\lt}{<}\) \(\newcommand{\gt}{>}\) \(\newcommand{\amp}{&}\) \(\definecolor{fillinmathshade}{gray}{0.9}\)Chapter 5 BIOL 235 Learning Outcomes
- Distinguish between catabolism and anabolism.
- Given a metabolic pathway, determine the substrates,products, and intermediate metabolites of the pathway.
- Describe the major characteristics of enzymes, including what kind of molecules they are, their role in the cell, and the purpose of the enzyme's active site
- Recognize the structure of ATP and know what kind of macromolecule it is.
- Given a description of an ATP-generating metabolism, determine whether it is substrate-level or oxidative phosphorylation.
- Recognize the structure of NAD+/NADH, know what kind of macromolecule it is, and what it is used for in metabolism.
- Explain why glycolysis and Krebs (TCA) cycle are considered Central Metabolism
Define precursor metabolite. - Explain what products of glycolysis and the TCA (Krebs) cycle will be useful to the cell and why (in what other process(es) will they be used?).
- Describe what happens in the 3 parts of glycolysis: energy investment, cleavage, energy generation.
- Describe the first reaction of the TCA (Krebs) cycle, including numbers of carbons in each major substrate and product involved.
- Explain where the carbon in the carbon dioxide generated by the Krebs (TCA) cycle originally came from in an organism using glucose as its carbon and energy source.
- Each time carbon dioxide is released during the Krebs (TCA) cycle, what else is produced?
- Explain (generally) what is happening during the "regeneration" portion of the Krebs (TCA) cycle.
- Identify where the following metabolites fit in to glycolysis and the Krebs (TCA) cycle: glucose, pyruvate, aceyl-CoA, citric acid, oxaloacetate, α-ketoglutarate (i.e. glycolysis or TCA; beginning, middle, end).
- 5.1: Energy, Matter, and Enzymes
- This page discusses metabolism, detailing the two main processes: catabolism, which breaks down molecules to release energy, and anabolism, which builds molecules using energy from ATP and NAD(P)H. It highlights the significance of oxidation-reduction reactions and electron carriers like NAD+ and FAD in energy transfer.
- 5.2: Central Metabolism
- This page discusses glycolysis and the TCA cycle as key metabolic pathways. Glycolysis breaks down glucose into pyruvate, producing ATP and NADH, and consists of three phases, yielding two ATP, two NADH, and two pyruvate per glucose. The TCA cycle converts pyruvate into acetyl-CoA, generating ATP, NADH, and FADH2 while releasing CO2, and also provides precursor metabolites for biosynthetic processes.
Thumbnail: "File:Citric Acid Cycle Diagram.png" by Krishnabp is licensed under CC BY-SA 4.0