12.6: Integergenic Non-coding RNAs- missing lincs in Stem/Cancer cells?
- Page ID
- 40990
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example: XIST
XIST was one of the first lincRNAs to be characterized. It is directly involved in deactivation of one of the female X chromosomes during embryonic development. It has been described as having the ability to ”crumple an entire chromosome”. This is important because deactivation prevents lethal overexpression of genes found on the X chromosome.
RNA is important for getting polychrome complex to chromosome ncRNAs can activate downstream genes in Cis, opposite in trans; Xist does the same thing.