1: What is a gene?
( \newcommand{\kernel}{\mathrm{null}\,}\)
At the end of this chapter, you should be able to:
- Appreciate the distinction between classical / transmission genetics and molecular genetics.
- Define the following vocabulary from transmission genetics: allele, homozygous, heterozygous, genotype, phenotype, dominant, recessive, test cross
- Propose a simple genetic model that is consistent with the result of a cross (with one or two traits with simple Mendelian inheritance.)
- Predict the genotypic and phenotypic ratios of a cross, given a genetic model.
- Apply the sum and product rules of probability to simple Mendelian crosses
- Explain how the central dogma connects DNA sequence to a protein's amino acid sequence.
- Predict the amino acid sequence that results from transcribing and translating a protein-coding gene.
- Recall the various types of point mutations in a protein-coding gene and predict their impact on the protein’s amino acid sequence.
- 1.2: Mendelian Genetics (Part I)
- Mendel's law of segregation. Genotype, phenotype, and alleles. Heterozygous/homozygous. 2 x 2 Punnett squares.
- 1.3: Mendelian Genetics (Part II)
- Mendel's law of independent assortment. Dihybrid crosses. 4 x 4 Punnett squares.
- 1.4: Probabilities in genetics
- The sum rule and product rule. Applying these rules to solve genetics problems involving many genes.