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Biology LibreTexts

7: Microbial Biochemistry

Thumbnail: An enzyme binding site that would normally bind substrate can alternatively bind a competitive inhibitor, preventing substrate access. Dihydrofolate reductase is inhibited by methotrexate which prevents binding of its substrate, folic acid. Binding site in blue, inhibitor in green, and substrate in black(PDB: 4QI9​). Image used with permission (CC BY 4.0; Thomas Shafee).