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- https://bio.libretexts.org/Bookshelves/Cell_and_Molecular_Biology/Fundamentals_of_Cell_Biology_(Dalton_and_Young)/04%3A_The_Endomembrane_System/4.01%3A_The_Endoplasmic_ReticulumThis page covers the endomembrane system's role in protein processing, lipid synthesis, and signaling. It highlights the endoplasmic reticulum (ER) as crucial for protein targeting, folding, and post-...This page covers the endomembrane system's role in protein processing, lipid synthesis, and signaling. It highlights the endoplasmic reticulum (ER) as crucial for protein targeting, folding, and post-translational modifications, with chaperone proteins preventing misfolding and relevant diseases. The text describes protein insertion mechanisms in the ER based on specific sequences, detailing the importance of transmembrane regions and bioinformatics in mapping protein domains and their functions
- https://bio.libretexts.org/Bookshelves/Cell_and_Molecular_Biology/Fundamentals_of_Cell_Biology_(Dalton_and_Young)/04%3A_The_Endomembrane_System/4.05%3A_End-of-Chapter_MaterialThis page discusses the endomembrane system, which includes the ER, Golgi apparatus, endosomes, and lysosomes, highlighting their roles in protein sorting and processing. It details the ER's function ...This page discusses the endomembrane system, which includes the ER, Golgi apparatus, endosomes, and lysosomes, highlighting their roles in protein sorting and processing. It details the ER's function as the protein entry point, the Golgi's processing of proteins, and the role of endosomes in cargo redirection. Additionally, it summarizes three scientific articles: Voelz et al. on Acyl-CoA binding protein, Weidman on Golgi transport, and Yuen et al.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/01%3A_Unit_I-_Structure_and_Catalysis/04%3A_The_Three-Dimensional_Structure_of_Proteins/4.10%3A_Protein_Aggregates_-_Amyloids_Prions_and_Intracellular_GranulesThis comprehensive biochemistry resource outlines the intricate processes leading to protein aggregation and their implications in diseases. It covers amyloid, prion, and protein aggregation types, th...This comprehensive biochemistry resource outlines the intricate processes leading to protein aggregation and their implications in diseases. It covers amyloid, prion, and protein aggregation types, the mechanisms of amyloid formation, and their connection to neurodegenerative illnesses like Alzheimer's and Parkinson's.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/Unit_IV_-_Special_Topics/28%3A_Biosignaling_-_Capstone_Volume_I/28.19%3A_Signal_Transduction_-__TemperatureThis page describes the mechanisms of temperature sensing and thermoregulation in mammals, exploring the roles of different ion channels, particularly TRP and TREK channels, in detecting thermal stimu...This page describes the mechanisms of temperature sensing and thermoregulation in mammals, exploring the roles of different ion channels, particularly TRP and TREK channels, in detecting thermal stimuli. It delves into how these channels contribute to the sensation of heat, cold, and thermal pain, with TREK channels playing a key role in moderating thermoreceptor activity by hyperpolarizing cells and TRP channels depolarizing them to increase excitability.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/01%3A_Unit_I-_Structure_and_Catalysis/05%3A_Protein_Function/5.06%3A__Binding_-_Conformational_Selections_and_Intrinsically_Disordered_ProteinsThe page outlines learning goals related to protein-ligand interactions, focusing on induced fit and conformational selection, intrinsically disordered proteins (IDPs), and Molecular Recognition Featu...The page outlines learning goals related to protein-ligand interactions, focusing on induced fit and conformational selection, intrinsically disordered proteins (IDPs), and Molecular Recognition Features (MoRFs). It describes models of protein-ligand binding, explores mechanisms of coupling folding and binding, and discusses the role of intrinsic disorder in cellular functions.
- https://bio.libretexts.org/Courses/Ouachita_Baptist_University/Reyna_Cell_Biology/02%3A_2-(T2-first_lecture)_Protein_Structure/2.04%3A_Protein_Folding_-_in_Vivo_and_in_Vitrointerpret spectral and chromatographic data from protein folding studies and use this to determine or explain a mechanism for folding explain the difference between the environments for protein foldin...interpret spectral and chromatographic data from protein folding studies and use this to determine or explain a mechanism for folding explain the difference between the environments for protein folding when performed in vitro and in vivo state the role of molecular chaperones in in vivo protein folding The proteins α and β subunits are in red and blue, and the iron-containing heme groups in green.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/01%3A_Unit_I-_Structure_and_Catalysis/05%3A_Protein_Function/5.8%3A__Problems_-_Predicting_Protein_Structure_and_Function_Using_Machine_Learning_and_AI_ProgramsThe document provides exercises and instructions for using machine learning/AI algorithms to predict protein structures, functions, and interactions, as well as design proteins with specific functions...The document provides exercises and instructions for using machine learning/AI algorithms to predict protein structures, functions, and interactions, as well as design proteins with specific functions. It emphasizes the use of tools such as AlphaFold, ESMFold, and iCn3D for modeling and rendering structures and interacting domains.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/01%3A_Unit_I-_Structure_and_Catalysis/04%3A_The_Three-Dimensional_Structure_of_Proteins/4.02%3A_Secondary_Structure_and_LoopsThe page provides a detailed exploration of secondary structures in proteins, focusing on alpha helices, beta sheets (parallel and antiparallel), 310 helices, pi helices, and loops and turns. It expla...The page provides a detailed exploration of secondary structures in proteins, focusing on alpha helices, beta sheets (parallel and antiparallel), 310 helices, pi helices, and loops and turns. It explains the roles of hydrogen bonds in stabilizing structures and discusses sequence determinants that influence structural propensities. The text also covers the characteristics and roles of loops, turns, and linkers, and examines amino acid propensities for forming different secondary structures.
- https://bio.libretexts.org/Courses/West_Los_Angeles_College/Biotechnology/02%3A_The_Molecules_of_Life/2.06%3A_ProteinsProteins are dynamic macromolecules that perform a wide variety of cellular functions. This page describes some of the functions of proteins, together with their structure, including the composition o...Proteins are dynamic macromolecules that perform a wide variety of cellular functions. This page describes some of the functions of proteins, together with their structure, including the composition of the amino acid, the formation of the peptide bond, and the four levels of protein structure.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/03%3A_Unit_III-_Information_Pathway/26%3A_Protein_Metabolism/26.03%3A_Translational_Regulation_and_Protein_DegradationThis page provides an extensive overview of the regulation of translation and protein degradation, focusing on translational regulation, ribosome structure heterogeneity, mRNA sequences, nascent pepti...This page provides an extensive overview of the regulation of translation and protein degradation, focusing on translational regulation, ribosome structure heterogeneity, mRNA sequences, nascent peptide effects, and the proteasome system.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/01%3A_Unit_I-_Structure_and_Catalysis/03%3A_Amino_Acids_Peptides_and_Proteins/3.2%3A_The_Structure_of_Proteins-_An_OverviewThis page covers the fundamentals of protein structure, detailing primary through quaternary levels. Primary structure involves the amino acid sequence, secondary structure focuses on repetitive motif...This page covers the fundamentals of protein structure, detailing primary through quaternary levels. Primary structure involves the amino acid sequence, secondary structure focuses on repetitive motifs like α-helices and β-sheets, tertiary structure describes 3D folding, and quaternary structure encompasses subunit organization. It also explores peptide bond formation, protein stability through chemical interactions, and methods for protein structure determination.
