This page covers the intricacies of allosterism in biochemistry, focusing on myoglobin, hemoglobin, and various enzymes, including lactate dehydrogenase and phosphofructokinases. It discusses structur...This page covers the intricacies of allosterism in biochemistry, focusing on myoglobin, hemoglobin, and various enzymes, including lactate dehydrogenase and phosphofructokinases. It discusses structural transformations in viral enzymes and the significance of Lenacapavir as an HIV drug. The text details the kinetic behaviors of enzymes and the influence of ligand concentrations on activity.
This page outlines learning goals for understanding protein-ligand interactions, including binding thermodynamics, key binding constants like Kd and Ka, and the interpretation of binding curves. It co...This page outlines learning goals for understanding protein-ligand interactions, including binding thermodynamics, key binding constants like Kd and Ka, and the interpretation of binding curves. It compares one-site versus two-site binding models and explores cooperative and allosteric effects. It discusses experimental methods for measuring interactions and relates binding to protein functions in biological contexts.
