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- https://bio.libretexts.org/Courses/Clinton_College/BIO_300%3A_Introduction_to_Genetics_(Neely)/06%3A_Regulation_of_Gene_Expression/6.02%3A_Eukaryotic_Gene_Regulation/6.2.01%3A_Gene_Expression_in_EvolutionMutations can occur in both cis-elements and trans-factors; both can result in altered patterns of gene expression. If an altered pattern of gene expression results in a selective advantage (or at lea...Mutations can occur in both cis-elements and trans-factors; both can result in altered patterns of gene expression. If an altered pattern of gene expression results in a selective advantage (or at least do not produce a major disadvantage), they may be selected and maintained in future populations. They may even contribute to the evolution of new species. An example of a sequence change in an enhancer is found in the Pitx gene.
- https://bio.libretexts.org/Courses/Clinton_College/BIO_300%3A_Introduction_to_Genetics_(Neely)/08%3A_Cancer_Genetics/8.06%3A__Genetics_and_Targeted_Cancer_Treatment__The_Story_of_Gleevec_(Imatinib)Thus the BCR-ABL tyrosine kinase enzyme exists only in cancer cells (and not in healthy cells) and a drug that inhibits this activity could be used to target and prevent the uncontrolled growth of the...Thus the BCR-ABL tyrosine kinase enzyme exists only in cancer cells (and not in healthy cells) and a drug that inhibits this activity could be used to target and prevent the uncontrolled growth of the cancerous CML cells.
- https://bio.libretexts.org/Courses/Clinton_College/BIO_300%3A_Introduction_to_Genetics_(Neely)/08%3A_Cancer_Genetics/8.01%3A__Classification_of_CancersCancers can be classified based on the tissues in which they originate. Sarcomas are cancers that originate in mesoderm tissues, such as bone or muscle, and cancers arising in glandular tissues (e.g. ...Cancers can be classified based on the tissues in which they originate. Sarcomas are cancers that originate in mesoderm tissues, such as bone or muscle, and cancers arising in glandular tissues (e.g. breast, prostate) are classified as adenocarcinomas. Carcinomas originate in epithelial cells (both inside the body and on its surface) and are the most common types of cancer (~85%)
- https://bio.libretexts.org/Courses/Clinton_College/BIO_300%3A_Introduction_to_Genetics_(Neely)/04%3A_Inheritance/4.04%3A_Exceptions_to_autosomal_inheritanceLoci on sex chromosomes do not adhere to Mendelian patterns of inheritance, because most of the loci on the typical X-chromosome are absent from the Y-chromosome, even though they act as a homologous ...Loci on sex chromosomes do not adhere to Mendelian patterns of inheritance, because most of the loci on the typical X-chromosome are absent from the Y-chromosome, even though they act as a homologous pair during meiosis. Instead, they will follow sex-linked patterns of inheritance.
- https://bio.libretexts.org/Courses/Clinton_College/BIO_300%3A_Introduction_to_Genetics_(Neely)/01%3A_Chemistry_to_Chromosomes/1.03%3A_MitosisRemembering that this is 3% of the DNA of only one of the 46 chromosomes in the human diploid cell, you can appreciate the problem faced by the cell of how to separate without error these great length...Remembering that this is 3% of the DNA of only one of the 46 chromosomes in the human diploid cell, you can appreciate the problem faced by the cell of how to separate without error these great lengths of DNA without creating horrible tangles. (courtesy J. A cell plate formed by the fusion of the vesicles of the phragmoplast grows from the center toward the cell walls, and the membranes of the vesicles fuse to form a plasma membrane that divides the cell in two.
- https://bio.libretexts.org/Courses/Clinton_College/BIO_300%3A_Introduction_to_Genetics_(Neely)/04%3A_Inheritance/4.02%3A__Mendelian_Genetics/4.2.02%3A_Dihybrid_Crosses_and_Independent_AssortmentMendel's Second Law, also called the Law of Independent Assortment, argues that two loci assort independently of each other during gamete formation. The commonly observed 9:3:3:1 phenotypic ratio that...Mendel's Second Law, also called the Law of Independent Assortment, argues that two loci assort independently of each other during gamete formation. The commonly observed 9:3:3:1 phenotypic ratio that is predicted from this law can also be obtained using Punnett Square
- https://bio.libretexts.org/Courses/Clinton_College/BIO_300%3A_Introduction_to_Genetics_(Neely)/08%3A_Cancer_Genetics/8.05%3A_Tumor_Suppressor_GenesMutation of p53, through formation of pyrimidine dimers in the genes following exposure to UV light, has been causally linked to squamous cell and basal cell carcinomas (but not melanomas, highlightin...Mutation of p53, through formation of pyrimidine dimers in the genes following exposure to UV light, has been causally linked to squamous cell and basal cell carcinomas (but not melanomas, highlighting the variety and complexities of mechanisms that can cause cancer).
- https://bio.libretexts.org/Courses/Clinton_College/BIO_300%3A_Introduction_to_Genetics_(Neely)/02%3A_Central_Dogma/2.03%3A_Genetic_Code_and_TranslationFigure \PageIndex7: The elongation cycle of translation begins with codon recognition in the A site by a tRNA with a complementary anticodon, then peptide bond formation and transfer of the amin...Figure \PageIndex7: The elongation cycle of translation begins with codon recognition in the A site by a tRNA with a complementary anticodon, then peptide bond formation and transfer of the amino acid to the A site tRNA, then translocation of the ribosome toward the 3 end of the mRNA for the next codon to be in the A site. (CC BY-NC-SA)
- https://bio.libretexts.org/Courses/University_of_Arkansas_Little_Rock/Genetics_BIOL3300_(Leacock)/Genetics_Textbook/04%3A_InheritanceExplore the topics of meiosis, recombination, Mendelian genetics, and extensions of these topics that connect to human genetics.
- https://bio.libretexts.org/Courses/University_of_Arkansas_Little_Rock/Genetics_BIOL3300_(Leacock)/Genetics_Textbook
- https://bio.libretexts.org/Courses/University_of_Arkansas_Little_Rock/Genetics_BIOL3300_(Leacock)/Genetics_Textbook/07%3A_Manipulating_and_Analyzing_Genes_and_Genomes/7.02%3A_Anthropological_GeneticsCertain features of the body, such as whether or not the epiphyseal plates are fused and the size of the pelvis if it belongs to an adult skeleton, can help us further identify remains. Further legisl...Certain features of the body, such as whether or not the epiphyseal plates are fused and the size of the pelvis if it belongs to an adult skeleton, can help us further identify remains. Further legislation was introduced in the wake of the HGP to protect people from being discriminated against based on their genetic information, including the Health Insurance Portability and Accountability Act (HIPAA) in 1996 and the Genetic Information Nondiscrimination Act (GINA) in 2008.
