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Biology LibreTexts

3.2: Consequences of mutations

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  • The effect of a mutation will depend upon the function of the DNA sequence.

    When mutations occur in coding sequences, we can predict the effect using the codon table.

    • Silent mutations: do not change the encoded amino acid
    • Nonsense mutations: change a codon to a STOP codon
    • Missense mutations: change a codon to a codon for a DIFFERENT amino acid
    • Frameshift mutations: add or remove bases to change all downstream codons

    Three is the magic number

    Adding or removing bases in multiples of three, will not cause a frameshift mutation. Why not?

    Would mutations like this affect the protein? What additional information would you need to make a prediction about such a mutation?

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