# 4.4: Feedback Loops

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Remember that homeostasis is the maintenance of a relatively stable internal environment. When a stimulus, or change in the environment, is present, feedback loops respond to keep systems functioning near a set point, or ideal level.

### Feedback

Feedback is a situation when the output or response of a loop impacts or influences the input or stimulus.

Typically, we divide feedback loops into two main types:

1. positive feedback loops, in which a change in a given direction causes additional change in the same direction.For example, an increase in the concentration of a substance causes feedback that produces continued increases in concentration.
2. negative feedback loops, in which a change in a given direction causes change in the opposite direction.For example, an increase in the concentration of a substance causes feedback that ultimately causes the concentration of the substance to decrease.

Positive feedback loops are inherently unstable systems. Because a change in an input causes responses that produce continued changes in the same direction, positive feedback loops can lead to runaway conditions. The term positive feedback is typically used as long as a variable has an ability to amplify itself, even if the components of a loop (receptor, control center and effector) are not easily identifiable. In most cases, positive feedback is harmful, but there are a few instances where positive feedback, when used in limited fashion, contributes to normal function. For example, during blood clotting, a cascade of enzymatic proteins activates each other, leading to the formation of a fibrin clot that prevents blood loss. One of the enzymes in the pathway, called thrombin, not only acts on the next protein in the pathway but also has an ability to activate a protein that preceded it in the cascade. This latter step leads to a positive feedback cycle, where an increase in thrombin leads to further increases in thrombin. It should be noted that there are other aspects of blood clotting that keep the overall process in check, such that thrombin levels don’t rise without limit. But if we just consider the effects of thrombin on itself, it is considered a positive feedback cycle. Although some may consider this a positive feedback loop, such terminology is not universally accepted.

Negative feedback loops are inherently stable systems. Negative feedback loops, in conjunction with the various stimuli that can affect a variable, typically produce a condition in which the variable oscillates around the set point. For example, negative feedback loops involving insulin and glucagon help to keep blood glucose levels within a narrow concentration range. If glucose levels get too high, the body releases insulin into the bloodstream. Insulin causes the body’s cells to take in and store glucose, lowering the blood glucose concentration. If blood glucose gets too low, the body releases glucagon, which causes the release of glucose from some of the body’s cells.

## Positive Feedback

In a positive feedback mechanism, the output of the system stimulates the system in such a way as to further increase the output. Common terms that could describe positive feedback loops or cycles include “snowballing” and “chain reaction”. Without a counter-balancing or “shut-down” reaction or process, a positive feedback mechanism has the potential to produce a runaway process. As noted, there are some physiologic processes that are commonly considered to be positive feedback, although they may not all have identifiable components of a feedback loop. In these cases, the positive feedback loop always ends with counter-signaling that suppresses the original stimulus.

A good example of positive feedback involves the amplification of labor contractions. The contractions are initiated as the baby moves into position, stretching the cervix beyond its normal position. The feedback increases the strength and frequency of the contractions until the baby is born. After birth, the stretching stops and the loop is interrupted.

Another example of positive feedback occurs in lactation, during which a mother produces milk for her infant. During pregnancy, levels of the hormone prolactin increase. Prolactin normally stimulates milk production, but during pregnancy, progesterone inhibits milk production. At birth, when the placenta is released from the uterus, progesterone levels drop. As a result, milk production surges. As the baby feeds, its suckling stimulates the breast, promoting further release of prolactin, resulting in yet more milk production. This positive feedback ensures the baby has sufficient milk during feeding. When the baby is weaned and no longer nurses from the mother, stimulation ceases and prolactin in the mother’s blood reverts to pre-breastfeeding levels.

The above provide examples of beneficial positive feedback mechanisms. However, in many instances, positive feedback can be potentially damaging to life processes. For example, blood pressure can fall significantly if a person loses a lot of blood due to trauma.

Blood pressure is a regulated variable that leads to the heart increasing its rate (i.e. heart rate increases) and contracting more strongly. These changes to the heart cause it to need more oxygen and nutrients, but if the blood volume in the body is too low, the heart tissue itself will not receive enough blood flow to meet these increased needs. The imbalance between oxygen demands of the heart and oxygen supply can lead to further heart damage, which actually lowers blood pressure, providing a larger change in the variable (blood pressure). The loop responds by trying to stimulate the heart even more strongly, leading to further heart damage…and the loop goes on until death ensues.

## Negative Feedback

Most biological feedback systems are negative feedback systems. Negative feedback occurs when a system’s output acts to reduce or dampen the processes that lead to the output of that system, resulting in less output. In general, negative feedback loops allow systems to self-stabilize. Negative feedback is a vital control mechanism for the body’s homeostasis.

You saw an example of a feedback loop applied to temperature and identified the components involved. This is an important example of how a negative feedback loop maintains homeostasis is the body’s thermoregulation mechanism. The body maintains a relatively constant internal temperature to optimize chemical processes. Neural impulses from heat-sensitive thermoreceptors in the body signal the hypothalamus. The hypothalamus, located in the brain, compares the body temperature to a set point value.

When body temperature drops, the hypothalamus initiates several physiological responses to increase heat production and conserve heat:

• Narrowing of surface blood vessels (vasoconstriction) decreases the flow of heat to the skin.
• Shivering commences, increasing production of heat by the muscles.
• Adrenal glands secrete stimulatory hormones such as norepinephrine and epinephrine to increase metabolic rates and hence heat production.

These effects cause body temperature to increase. When it returns to normal, the hypothalamus is no longer stimulated, and these effects cease.

When body temperature rises, the hypothalamus initiates several physiological responses to decrease heat production and lose heat:

• Widening of surface blood vessels (vasodilation) increases the flow of heat to the skin and get flushed.
• Sweat glands release water (sweat) and evaporation cools the skin.

These effects cause body temperature to decrease. When it returns to normal, the hypothalamus is no longer stimulated, and these effects cease.

Many homeostatic mechanisms, like temperature, have different responses if the variable is above or below the set point. When temperature increases, we sweat, when it decreases, we shiver. These responses use different effectors to adjust the variable. In other cases, a feedback loop will use the same effector to adjust the variable back toward the set point, whether the initial change of the variable was either above or below the set point. For example, pupillary diameter is adjusted to make sure an appropriate amount of light is entering the eye. If the amount of light is too low, the pupil dilates, if it is too high, the pupil constricts.

This might be compared to driving. If your speed is above the set point (the value you want it to be), you can either just decrease the level of the accelerator (i.e. coast), or you can active a second system — the brake. In both cases you slow, but it can be done by either just “backing” off on one system, or adding a second system.

Let’s look at how these two examples work related to normal blood pressure homeostasis.

Blood pressure is measured as the circulating blood puts pressure on the walls of the body’s arteries. Blood pressure is created initially by the contraction of the heart. Changes in the strength and rate of contraction will be directly related to changes in blood pressure. Changes in the volume of blood would also be directly related to changes in blood pressure. Changes in the diameter of the vessels that blood travels through will change resistance and have an opposite change on blood pressure. Blood pressure homeostasis involves receptors monitoring blood pressure and control centers initiating changes in the effectors to keep it within a normal range.

## Self-Check Questions

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