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22.7: Functions of the Female Reproductive System

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  • Waiting Expectantly

    A mother-to-be waits patiently for her fetus to grow as her belly swells. Reproduction is all about making babies, and the female reproductive system is specialized for this purpose. Its functions include producing gametes called eggs, secreting sex hormones (such as estrogen), providing a site for fertilization, gestating a fetus if fertilization occurs, giving birth to a baby, and breastfeeding a baby after birth. The only thing missing is sperm.

    Pregnant woman

    Figure \(\PageIndex{1}\): Pregnant woman

    Egg Production

    At birth, ovaries contain all the eggs that will ever be produced, which may include a million or more eggs. The eggs don't start to mature, however, until a female enters puberty and attains sexual maturity. After that, one egg typically matures each month and is released from an ovary. This continues until menopause (cessation of monthly periods), typically by age 52. By then, viable eggs may be almost depleted, and hormone levels can no longer support the monthly cycle. During the reproductive years, which of the two ovaries releases an egg in a given month seems to be a matter of chance. Occasionally, both ovaries will release an egg at the same time. If both eggs are fertilized, the offspring are fraternal twins (dizygotic, or "two-zygote," twins), and they are no more alike genetically than non-twin siblings.


    The process of producing eggs in the ovaries of a fetus carrying XX chromosomes is called oogenesis. Eggs are haploid gametes, and their production occurs in several steps that involve different types of cells, as summarized in Figure \(\PageIndex{2}\). Oogenesis is completed long before birth. It occurs when diploid germ cells called oogonia (singular, oogonium) undergo mitosis. Each such cell division produces two diploid cells. One is called the primary oocyte, and the other is retained to help maintain a reserve of oogonia. The primary oocyte, in turn, starts to go through the first cell division of meiosis (meiosis I). However, it does not complete meiosis I until much later. Instead, it remains in a resting state, nestled within a tiny, immature follicle in the ovary until the person goes through puberty.


    Figure \(\PageIndex{2}\): Formation of a secondary oocyte that may become a zygote begins with mitosis of an oogonium. This is followed by two meiotic cell divisions. In humans, the first polar body does not undergo the second meiotic division illustrated here.

    Maturation of a Follicle

    Beginning in puberty, about once a month, one of the follicles in an ovary undergoes maturation, and an egg is released. As the follicle matures, it goes through changes in the numbers and types of its cells. The primary oocyte within the follicle also resumes meiosis. It completes meiosis I, which began long before birth, to form a secondary oocyte and a smaller cell, called the first polar body. Both the secondary oocyte and the first polar body are haploid cells. The secondary oocyte has most of the cytoplasm from the primary oocyte and is much larger than the first polar body, which soon disintegrates and disappears. The secondary oocyte begins meiosis II, but only completes it if the egg is fertilized.

    Release of an Egg

    It typically takes 12 to 14 days for a follicle to mature in an ovary, and for the secondary oocyte to form. Then, the follicle bursts open and the ovary ruptures, releasing the secondary oocyte from the ovary. This event is called ovulation. The now-empty follicle starts to change into a structure called a corpus luteum. The expelled secondary oocyte is usually swept into the nearby Fallopian tube by its waving, fingerlike fimbriae.

    Uterine Changes

    While the follicle is maturing in the ovary, the uterus is also undergoing changes to prepare it for an embryo if fertilization occurs. For example, the endometrium gets thicker and becomes more vascular. Around the time of ovulation, the cervix undergoes changes that help sperm reach the oocyte to fertilize it. The cervical canal widens, and the cervical mucus becomes thinner and more alkaline. These changes help promote the passage of sperm from the vagina into the uterus and make the environment more hospitable to sperm.

    Fertilization — or Not

    Fertilization of an egg by a sperm normally occurs in a Fallopian tube, most often in the part of the tube that passes above the ovary (Figure \(\PageIndex{3}\)). In order for fertilization to occur, sperm must “swim” from the vagina where they are deposited, through the cervical canal to the uterus, and then through the body of the uterus to one of the Fallopian tubes. Once sperm enters a Fallopian tube, tubular fluids help carry them through the tube toward the secondary oocyte at the other end. The secondary oocyte also functions to promote fertilization. It releases molecules that guide the sperm and allow the surface of the egg to attach to the surface of the sperm. The egg can then absorb the sperm, allowing fertilization to occur.

     Fertilization human reproductive system
    Figure \(\PageIndex{3}\): This diagram shows the structures through which sperm must pass if fertilization of an egg is to occur. It also shows the event of fertilization, and where fertilization usually occurs.

    If Fertilization Occurs

    If the secondary oocyte is fertilized by a sperm as it passes through the Fallopian tube, the secondary oocyte quickly completes meiosis II, forming a diploid zygote and another polar body. (This second polar body, like the first, normally breaks down and disappears.) The zygote then continues the journey through the Fallopian tube to the uterus, during which it undergoes several mitotic cell divisions. By the time it reaches the uterus up to five days after fertilization, it consists of a ball of cells called a blastocyst. Within another day or two, the blastocyst implants itself in the endometrium lining the uterus, and gestation begins.

    If Fertilization Does Not Occur

    What happens if the secondary oocyte is not fertilized by a sperm as it passes through the Fallopian tube? It continues on its way to the uterus without ever completing meiosis II. It is likely to disintegrate within a few days while still in the Fallopian tube. Any remaining material will be shed from the woman’s body during the next menstrual period.


    Pregnancy is the carrying of one or more offspring from fertilization until birth. This is one of the major functions of the female reproductive system. It involves virtually every other body system including the cardiovascular, urinary, and respiratory systems, to name just three. The maternal organism plays a critical role in the development of the offspring. They must provide all the nutrients and other substances needed for normal growth and development of the offspring, and they must also remove the wastes excreted by the offspring. Most nutrients are needed in greater amounts by a pregnant individual to meet fetal needs, but some are especially important, including folic acid, calcium, iron, and omega-3 fatty acids. A healthy diet, along with prenatal vitamin supplements, is recommended for the best pregnancy outcome. A pregnant person should also avoid ingesting substances (such as alcohol) that can damage the developing offspring, especially early in the pregnancy when all of the major organs and organ systems are forming.

    When counted from the first day of the last menstrual period, the average duration of pregnancy is about 40 weeks (38 weeks when counted from the time of fertilization), but a pregnancy that lasts between 37 and 42 weeks is still considered within the normal range. From the point of view of the maternal organism, the total duration of pregnancy is typically divided into three periods, called trimesters, each of which lasts about three months. This division of the total period of gestation is useful for summarizing the typical changes during pregnancy. From the point of view of the developing offspring, however, the major divisions are different. They are the embryonic and fetal stages. The offspring is called an embryo from the time it implants in the uterus through the first eight weeks of life. After that, it is called a fetus for the duration of the pregnancy.

    First Trimester

    The first trimester begins at the time of fertilization and lasts for the next 12 weeks. Even before a pregnant person knows they are pregnant, they may experience signs and symptoms of pregnancy. They may notice a missed menstrual period, and they may also experience a tender nipple area, increased appetite, and more frequent urination. Many individuals also experience nausea and vomiting in the first trimester. This is often called “morning sickness,” because it commonly occurs in the morning, but it may occur at any time of day. Some lose weight during the first trimester because of morning sickness.

    Second Trimester

    The second trimester occurs during weeks 13 to 28 of pregnancy. A pregnant person may feel more energized during this trimester. If she experienced nausea and vomiting during the first trimester, these symptoms often subside during the second trimester. Weight gain starts occurring during this trimester, as well. By about week 20, the fetus is getting large enough that the mother can feel its movements. The photo on the left in Figure \(\PageIndex{4}\) shows a pregnant woman at week 26, toward the end of the second trimester. (For comparison, the same woman is shown on the right of Figure \(\PageIndex{4}\) at the end of the third trimester.)

    Third Trimester

    The third trimester occurs during weeks 29 through birth (at about 40 weeks). During this trimester, the uterus expands rapidly, making up a larger and larger portion of the woman's abdomen. Weight gain is also more rapid. During the third trimester, the movements of the fetus become stronger and more frequent, and they may become disruptive to the mother. As the fetus grows larger, its weight and the space it takes up may lead to symptoms in the mother such as back pain, swelling of the lower extremities, more frequent urination, varicose veins, and heartburn. By the end of the third trimester, the woman's abdomen often will transform in shape as it drops, due to the fetus turning to a downward position before birth so its head rests on the cervix. This relieves pressure on the upper abdomen, but reduces bladder capacity and increases pressure on the pelvic floor and rectum.

    Pregnancy comparison
    Figure \(\PageIndex{4}\): The same woman is shown in both photos: on the left at week 26 of the pregnancy, and on the right at week 40 of the pregnancy


    Near the time of birth, the amniotic sac — a fluid-filled membrane that encloses the fetus within the uterus — breaks in a gush of fluid. This is commonly called “breaking water.” Labor usually begins within a day of this event, although it may begin prior to it. Labor is the general term for the process of childbirth in which regular uterine contractions push the fetus and placenta out of the body. Labor can be divided into three stages, which are illustrated in Figure \(\PageIndex{5}\): dilation, birth, and after birth.

    1. During the dilation stage of labor, uterine contractions begin and become increasingly frequent and intense. The contractions push the baby’s head (most often) against the cervix, causing the cervical canal to dilate, or become wider. This lasts until the cervical canal has dilated to about 10 cm (3.9 in.) in width, which may take 12 to 20 hours — or even longer. The cervical canal must be dilated to this extent in order for the baby’s head to fit through it.
    2. During birth, the baby descends (usually headfirst) through the cervical canal and vagina, and into the world outside. This is the stage when the mother generally starts bearing down during the contractions to help push out the fetus. This stage may last from about 20 minutes to two hours or more. Usually, within a minute or less of birth, the umbilical cord is cut, so the baby is no longer connected to the placenta.
    3. During the afterbirth stage, the placenta is delivered. This stage may last from a few minutes to a half hour.
    Stages of Childbirth
    Figure \(\PageIndex{5}\): The three stages of labor are dilation of the cervix, the birth of the baby, and the delivery of the afterbirth (placenta)

    Delivery is a matter of concern for all individuals, however, additional concerns arise for individuals with disabilities. According to a study done by Lipson and Rogers, delivery decisions for disabled individuals are made arbitrarily without their content. They are forced to deliver via cesarean section because they think that a disabled person wouldn't be able to handle the process. 


    Although the breasts or chest are not classified as organs of the reproductive system, they nonetheless may play an important role in reproduction. The physiological function of the nipples is lactation or the production of milk to feed an infant. This function is illustrated in Figure \(\PageIndex{6}\). Besides nutrients, the milk provides hormones, antibodies, and other substances that help ensure a healthy start after birth.

    Figure \(\PageIndex{6}\) shows the correct way for an infant to suck the nipples to stimulate the letdown of milk from the mammary glands. The letdown of milk when an infant sucks at the nipple is one of the few examples of positive feedback in the human organism. Sucking causes a release from the posterior pituitary gland of the hypothalamic hormone oxytocin. Oxytocin, in turn, causes milk to flow from the alveoli in the glands where milk is produced, through the milk ducts, and into the milk sacs behind the areola. You can trace this route of milk in Figure \(\PageIndex{6}\). The baby can suck the milk out of the sacs through the nipple, where they converge. The release of milk stimulates the baby to continue sucking, which in turn keeps the milk flowing.

    Breastfeeding hormonal stimulations
    Figure \(\PageIndex{6}\): The physiological function of the human breast is to provide nourishment and other substances to an infant.

    In 2018, during a survey, the respondents mentioned about two protocols of lactation induction in a trans woman, Zil Goldstein and  Newman-Goldfarb protocols, which was initially designed for a cis woman to nurse a baby born to a surrogate mother. The Zil Goldstein protocol starts with 10 mg domperidone (a drug) three times daily while the Newman-Goldfarb protocol recommends 10 mg domperidone four times daily. Both regimens subsequently increase the dose to 20 mg four times daily. Since domperidone is not approved by the Food and Drug Administration, the patients obtain the drug elsewhere. Both regimens also utilize estradiol and progesterone sex hormones. Subsequently, the physical stimulation of the nipples is recommended for milk production. Informal reports of trans women who induced lactation have emerged recently. However, there are no data to support any of the other reports. There is a critical gap in evidence-based medicine for this population.

    Sex Hormones

    Traditionally, a person carrying XX chromosomes is considered Female sex. Female reproduction could not occur without sex hormones released by the ovaries. These hormones include estrogen and progesterone.


    Before birth, estrogen is released by the gonads in fetuses with XX chromosomes and leads to the development of female reproductive organs. At puberty, estrogen levels rise and are responsible for sexual maturation, and for the development of female secondary sex characteristics. Estrogen is also needed to help regulate the menstrual cycle and ovulation throughout the reproductive years. Estrogen is produced primarily by follicular cells in the ovaries. During pregnancy, estrogen is also produced by the placenta. There are actually three forms of estrogen in the human female: estradiol, estriol, and estrone.

    1. Estradiol is the predominant form of estrogen during the reproductive years. It is also the most potent form of estrogen.
    2. Estriol is the predominant form of estrogen during pregnancy. It is also the weakest form of estrogen.
    3. Estrone is the predominant form of estrogen in post-menopausal women. It is intermediate in strength between the other two forms of estrogen.


    Progesterone stands for “pro-gestational hormone.” It is synthesized and secreted primarily by the corpus luteum in the ovary. Progesterone plays many physiological roles but is best known for its role during pregnancy. In fact, it is sometimes called the “hormone of pregnancy.” Among other functions, progesterone prepares the uterus for pregnancy each month by building up the uterine lining. If pregnancy occurs, progesterone helps maintain the pregnancy in a number of ways, such as decreasing the maternal immune response to the genetically different embryo and decreasing the ability of uterine muscle tissue to contract. Progesterone also prepares the mammary glands for lactation during pregnancy, and withdrawal of progesterone after birth is one of the triggers of milk production.

    Feature: Myth vs. Reality

    There are many myths associated with pregnancy. Most are harmless, but some may put the pregnant woman or fetus at risk. As always, knowledge is power.

    Myth: You should avoid petting your cat during pregnancy.

    Reality: Cat feces may be contaminated with microscopic parasites that can cause a disease called toxoplasmosis. Pregnant women who contract this disease are at risk of stillbirth, miscarriage, or giving birth to an infant with serious health problems. Pregnant women should not have contact with a cat’s litter box or feces, but petting a cat poses no real risk of infection.

    Myth: You should not dye your hair during pregnancy, because the chemicals can harm the fetus.

    Reality: Whereas some chemicals (such as certain pesticides) have been shown to be associated with birth defects, there is no evidence that using hair dye during pregnancy increases this risk.

    Myth: A pregnant woman needs to eat for two, so she should double her pre-pregnancy caloric intake.

    Reality: Throughout a typical pregnancy, a person needs only about 300 extra calories per day, on average, to support her growing fetus. Most of the extra calories are needed during the last trimester when the fetus is growing most rapidly. Doubling her caloric intake during pregnancy is likely to cause too much weight gain, which can be detrimental to her baby. Babies that weigh much more than the average 7.5 pounds at birth are more likely to develop diabetes and obesity in later life.

    Myth: Women who are pregnant have strange food cravings, such as ice cream with pickles.

    Reality: Some women do have food cravings during pregnancy, but they are not necessarily cravings for strange foods or unusual food combinations. For example, a pregnant woman might crave starchy foods for a few weeks, or she may be put off by certain foods that she loved before pregnancy.

    Myth: A pregnant woman has skin that glows.

    Reality: Pregnancy can actually be hard on the skin and its appearance. Besides stretch marks on the abdomen and breasts, pregnancy may lead to spider veins, varicose veins, new freckles, darkening of moles, and acne flare-ups. In addition, as many as 75 percent of pregnant women experience chloasma, which is the emergence of blotchy brown patches of skin on the face due to high estrogen levels. Chloasma is often referred to as the “mask of pregnancy.”

    Myth: Men cannot carry a baby.

    Reality: Transgender men can get pregnant using alternative methods. 


    • Oogenesis is the process of producing eggs in the ovaries of a fetus carrying XX chromosomes. Oogenesis begins when a diploid oogonium divides by mitosis to produce a diploid primary oocyte. The primary oocyte begins meiosis I and then remains at this stage in an immature ovarian follicle until after birth. By birth, ovaries contain all the eggs she will ever produce, numbering at least a million.
    • After puberty, one follicle a month matures, and its primary oocyte completes meiosis I to produce a secondary oocyte, which begins meiosis II. During ovulation, the mature follicle bursts open, and the secondary oocyte leaves the ovary and enters a Fallopian tube.
    • While a follicle is maturing in an ovary each month, the endometrium in the uterus is building up to prepare for an embryo. Around the time of ovulation, cervical mucus becomes thinner and more alkaline to help sperm reach the secondary oocyte.
    • If the secondary oocyte is fertilized by a sperm, it quickly completes meiosis II and forms a diploid zygote, which will continue through the Fallopian tube. The zygote will go through multiple cell divisions before reaching and implanting in the uterus. If the secondary oocyte is not fertilized, it will not complete meiosis II, and it will soon disintegrate.
    • Pregnancy is the carrying of one or more offspring from fertilization until birth. The maternal organism must provide all the nutrients and other substances needed by the developing offspring, and also remove its wastes. She should also avoid exposures that could potentially damage the offspring, especially early in the pregnancy when organ systems are developing.
    • The average duration of pregnancy is 40 weeks (from the first day of the last menstrual period) and is divided into three trimesters of about three months each. Each trimester is associated with certain events and conditions that a pregnant woman may expect, such as morning sickness during the first trimester, feeling fetal movements for the first time during the second trimester, and rapid weight gain in both fetus and mother during the third trimester.
    • Labor, which is the general term for the birth process, usually begins around the time the amniotic sac breaks and its fluid leaks out. Labor occurs in three stages: dilation of the cervix, the birth of the baby, and delivery of the placenta (afterbirth).
    • The physiological function of nipples in the chest area is lactation or the production of milk to feed an infant. Sucking on the nipples by the infant stimulates the release of the hypothalamic hormone oxytocin from the posterior pituitary, which causes the flow of milk. The release of milk stimulates the baby to continue sucking, which in turn keeps the milk flowing. This is one of the few examples of positive feedback in the human organism.
    • The ovaries produce sex hormones, including estrogen and progesterone. Estrogen is responsible for sexual differentiation before birth, as well as for sexual maturation and the development of secondary sex characteristics at puberty. It is also needed to help regulate the menstrual cycle and ovulation after puberty and until menopause. Progesterone prepares the uterus for pregnancy each month during the menstrual cycle and helps maintain the pregnancy if fertilization occurs.


    1. What is oogenesis? How does it occur?

    2. Describe the maturation of an ovarian follicle.

    3. Define ovulation.

    4. What is happening in the uterus while a follicle in the ovary is maturing?

    5. After a secondary oocyte is ovulated from the ovary, it may or may not be fertilized. Contrast what happens next in each of these different outcomes.

    6. What is pregnancy, and what is the role of the maternal organism in pregnancy?

    7. What is the average duration of pregnancy? Identify the trimesters of pregnancy.

    8. Define labor. What event is often a sign that labor will soon begin?

    9. Identify the stages of labor.

    10. Describe the physiological function of female breasts. How is this function controlled?

    11. Identify the functions of the female sex hormones estrogen and progesterone.

    12. True or False: All of the developing gametes in an ovary complete meiosis I at the time of puberty.

    13. True or False: After fertilization, meiosis II is completed, and then mitosis occurs.

    14. A fertilized egg that has not yet implanted in the uterus is called a(n) ________________.

    A. embryo

    B. zygote

    C. fetus

    D. secondary oocyte

    15. Describe the roles of the cervix in fertilization and childbirth.

    Explore More

    Mothers can't always be with their babies, and they may need to pump breast milk so the baby will have a source of food while they are away. Learn how to use a breast pump here:


    1. Pregnant woman by Øyvind Holmstad, CC BY-SA 4.0 via Wikimedia Commons
    2. Oogenesis by OpenStax College, CC BY 3.0 via Wikimedia Commons
    3. Fertilization by staff (2014). "Medical gallery of Blausen Medical 2014". WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436. licensed CC BY 3.0 via Wikimedia Commons
    4. Pregnancy comparison by Maustrauser, public domain via Wikimedia Commons
    5. Stages of labor by OpenStax College, CC BY 3.0 via Wikimedia Commons
    6. Let down reflex by OpenStax College, CC BY 3.0 via Wikimedia Commons
    7. Text adapted from Human Biology by CK-12 licensed CC BY-NC 3.0
    8. Some text is adapted from Trautner, Emily et al. “Knowledge and practice of induction of lactation in trans women among professionals working in trans health.” International breastfeeding journal vol. 15,1 63. 16 Jul. 2020, doi:10.1186/s13006-020-00308-6CC BY 4.0