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Biology LibreTexts

H. Protein Aggregates and Disease

Skills to Develop

  • describe experimental evidence to show that protein misfolding and aggregation depends on the amino acid sequence and the environment in which folding occurs.
  • describe conditions in vitro that may promote aggregation and how these might be minimized in vivo
  • describe alternative conformations of prion proteins and relate them to a energy topology landscape
  • explain how prion diseases may be transmitted in the absence of genetic material

Thumbnail: Structure of human hemoglobin. The proteins α and β subunits are in red and blue, and the iron-containing heme groups in green. From PDB: 1GZX​. Image used with permission (GNU; Proteopedia Hemoglobin).