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Biology LibreTexts

G. Predicting Protein Properties From Sequences

Skills to Develop

  • find web based proteomics protein to analyze protein sequences and structures
  • describe the basis for methods used to predict the secondary structure and hydrophobic structures of proteins
  • analyze secondary structure and hydropathy plots from web-based proteomics programs.
  • describe differences between integral and peripheral membranes proteins, and how each could be purified.
  • explain how hydropathy and secondary structure plots can be used to predict membrane spanning sequences of proteins
  • describe in general the theoretical and empirically based methods to predict protein tertiary structure from a primary sequence
  • describe possible early intermediates in protein folding as determined by theoretical methods

Thumbnail: Structure of human hemoglobin. The proteins α and β subunits are in red and blue, and the iron-containing heme groups in green. From PDB: 1GZX​. Image used with permission (GNU; Proteopedia Hemoglobin).