Skip to main content
Biology LibreTexts

7.9: Nucleotide Metabolism

Arguably, the most interesting metabolic pathways from the perspective of regulation are those leading to the synthesis of nucleotides. We shall consider ribonucleotide synthesis from from scratch ( de novo synthesis). Deoxyribonucleotide synthesis from ribonucleotides will be considered separately.

Synthesis of ribonucleotides by the de novo method occurs in two pathways – one for purines and one for pyrimidines. What is notable about both of these pathways is that nucleotides are built from very simple building blocks.


Dr. Kevin Ahern and Dr. Indira Rajagopal (Oregon State University)