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- https://bio.libretexts.org/Workbench/Bio_11A_-_Introduction_to_Biology_I/18%3A_DNA_Technologies/18.08%3A_Chapter_SummaryOnce replication is completed, the RNA primers are replaced by DNA nucleotides and the DNA is sealed with DNA ligase, which creates phosphodiester bonds between the 3'-OH of one end and the 5' phospha...Once replication is completed, the RNA primers are replaced by DNA nucleotides and the DNA is sealed with DNA ligase, which creates phosphodiester bonds between the 3'-OH of one end and the 5' phosphate of the other strand. The ends of the chromosomes pose a problem as the primer RNA at the 5’ ends of the DNA cannot be replaced with DNA, and the chromosome is progressively shortened.
- https://bio.libretexts.org/Courses/Norco_College/OpenStax_Biology_2e_for_Norco_College/14%3A_DNA_Structure_and_Function/14.08%3A_Chapter_SummaryOnce replication is completed, the RNA primers are replaced by DNA nucleotides and the DNA is sealed with DNA ligase, which creates phosphodiester bonds between the 3'-OH of one end and the 5' phospha...Once replication is completed, the RNA primers are replaced by DNA nucleotides and the DNA is sealed with DNA ligase, which creates phosphodiester bonds between the 3'-OH of one end and the 5' phosphate of the other strand. The ends of the chromosomes pose a problem as the primer RNA at the 5’ ends of the DNA cannot be replaced with DNA, and the chromosome is progressively shortened.
- https://bio.libretexts.org/Workbench/Bio_11A_-_Introduction_to_Biology_I/21%3A_Mutations/21.06%3A_Chapter_SummaryMutations Most mistakes in DNA replication are corrected, but if they are not, they may result in a mutation, defined as a permanent change in the DNA sequence. Mutations can be of many types, such as...Mutations Most mistakes in DNA replication are corrected, but if they are not, they may result in a mutation, defined as a permanent change in the DNA sequence. Mutations can be of many types, such as substitution, deletion, insertion, and trinucleotide repeat expansions. Mutations in repair genes may lead to serious consequences such as cancer. Mutations can be induced or may occur spontaneously.
- https://bio.libretexts.org/Courses/City_College_of_San_Francisco/Introduction_to_Genetics/07%3A_DNA_Structure_and_Function/7.09%3A_Chapter_SummaryOnce replication is completed, the RNA primers are replaced by DNA nucleotides and the DNA is sealed with DNA ligase, which creates phosphodiester bonds between the 3'-OH of one end and the 5' phospha...Once replication is completed, the RNA primers are replaced by DNA nucleotides and the DNA is sealed with DNA ligase, which creates phosphodiester bonds between the 3'-OH of one end and the 5' phosphate of the other strand. The ends of the chromosomes pose a problem as the primer RNA at the 5’ ends of the DNA cannot be replaced with DNA, and the chromosome is progressively shortened.
- https://bio.libretexts.org/Workbench/Bio_11A_-_Introduction_to_Biology_I/17%3A_DNA_Replication/17.07%3A_Chapter_SummaryOnce replication is completed, the RNA primers are replaced by DNA nucleotides and the DNA is sealed with DNA ligase, which creates phosphodiester bonds between the 3'-OH of one end and the 5' phospha...Once replication is completed, the RNA primers are replaced by DNA nucleotides and the DNA is sealed with DNA ligase, which creates phosphodiester bonds between the 3'-OH of one end and the 5' phosphate of the other strand. The ends of the chromosomes pose a problem as the primer RNA at the 5’ ends of the DNA cannot be replaced with DNA, and the chromosome is progressively shortened.
- https://bio.libretexts.org/Workbench/Bio_11A_-_Introduction_to_Biology_I/16%3A_DNA_Structure_and_Function/16.06%3A_Chapter_SummaryChargaff found that the ratio of A = T and C = G, and that the percentage content of A, T, G, and C is different for different species. Some of the salient features are that the two strands that make ...Chargaff found that the ratio of A = T and C = G, and that the percentage content of A, T, G, and C is different for different species. Some of the salient features are that the two strands that make up the double helix have complementary base sequences and anti-parallel orientations. Alternating deoxyribose sugars and phosphates form the backbone of the structure, and the nitrogenous bases are stacked like rungs inside.
