Importantly, competitive inhibition can be overcome by increasing substrate concentration, as this raises the probability of the substrate out-competing the inhibitor for the active site. Competitive ...Importantly, competitive inhibition can be overcome by increasing substrate concentration, as this raises the probability of the substrate out-competing the inhibitor for the active site. Competitive inhibition often serves as a rapid, reversible way to control metabolic pathways, while noncompetitive inhibition allows for more complex regulation, as the allosteric site can respond to molecules unrelated to the substrate.