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- https://bio.libretexts.org/Courses/Manchester_Community_College_(MCC)/BIOL_106%3A_Essentials_of_Anatomy_and_Physiology_(Anzalone)/03%3A_Cell_Structure_and_Function/3.23%3A_Mutations_and_CancerYour cells may grow and divide without performing their necessary functions, or without fully replicating their DNA, or without copying their organelles. Probably not much good could come of that. So ...Your cells may grow and divide without performing their necessary functions, or without fully replicating their DNA, or without copying their organelles. Probably not much good could come of that. So the cell cycle needs to be highly regulated and tightly controlled. And it is.
- https://bio.libretexts.org/Courses/Folsom_Lake_College/BIOL_310%3A_General_Biology_(Wada)/04%3A_Cell_Division/4.01%3A_Reproduction_at_the_Cellular_Level/4.1.03%3A_Cancer_and_the_Cell_CycleCancer is the result of unchecked cell division caused by a breakdown of the mechanisms regulating the cell cycle. The loss of control begins with a change in the DNA sequence of a gene that codes for...Cancer is the result of unchecked cell division caused by a breakdown of the mechanisms regulating the cell cycle. The loss of control begins with a change in the DNA sequence of a gene that codes for one of the regulatory molecules. Faulty instructions lead to a protein that does not function as it should. Any disruption of the monitoring system can allow other mistakes to be passed on to the daughter cells. Each successive cell division will give rise to daughter cells with even more damage.
- https://bio.libretexts.org/Workbench/BIOL_190%3A_General_Biology_(OpenStax)/02%3A_Unit_II-_The_Cell/2.07%3A_Cell_Reproduction/2.7.05%3A_Cancer_and_the_Cell_CycleCancer is the result of unchecked cell division caused by a breakdown of the mechanisms that regulate the cell cycle. The loss of control begins with a change in the DNA sequence of a gene that codes ...Cancer is the result of unchecked cell division caused by a breakdown of the mechanisms that regulate the cell cycle. The loss of control begins with a change in the DNA sequence of a gene that codes for one of the regulatory molecules. Faulty instructions lead to a protein that does not function as it should. Any disruption of the monitoring system can allow other mistakes to be passed on to the daughter cells. Each successive cell division will give rise to daughter cells with even more damage
- https://bio.libretexts.org/Workbench/Principles_of_the_Human_Body/13%3A_Cell_Reproduction/13.4%3A_Mutations_and_CancerYour cells may grow and divide without performing their necessary functions, or without fully replicating their DNA, or without copying their organelles. Probably not much good could come of that. So ...Your cells may grow and divide without performing their necessary functions, or without fully replicating their DNA, or without copying their organelles. Probably not much good could come of that. So the cell cycle needs to be highly regulated and tightly controlled. And it is.
- https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/12%3A_Cancer/12.05%3A_BCL-2This page discusses BCL-2, a proto-oncogene on chromosome 18 involved in cancer by inhibiting apoptosis in B-cells. Its translocation with chromosome 14 (t(14;18)) results in Bcl-2 overexpression, aid...This page discusses BCL-2, a proto-oncogene on chromosome 18 involved in cancer by inhibiting apoptosis in B-cells. Its translocation with chromosome 14 (t(14;18)) results in Bcl-2 overexpression, aiding evasion of programmed cell death, thus promoting cancer. However, this translocation alone does not guarantee cancer, as many carriers remain healthy; other mutations, such as c-myc translocation, also play a role in B-cell malignancies.
- https://bio.libretexts.org/Courses/Butte_College/BC%3A_BIOL_2_-_Introduction_to_Human_Biology_(Grewal)/Text/07%3A_Cell_Reproduction/7.4%3A_Mutations_and_CancerYour cells may grow and divide without performing their necessary functions, or without fully replicating their DNA, or without copying their organelles. Probably not much good could come of that. So ...Your cells may grow and divide without performing their necessary functions, or without fully replicating their DNA, or without copying their organelles. Probably not much good could come of that. So the cell cycle needs to be highly regulated and tightly controlled. And it is.
- https://bio.libretexts.org/Courses/University_of_Arkansas_Little_Rock/Genetics_BIOL3300_(Leacock)/Genetics_Textbook/08%3A_Cancer_Genetics/8.04%3A_OncogenesGenes that are a part of the normal regulation of cell division, but which after mutation contribute to cancer, are called proto-oncogenes. Once a proto-oncogene has been abnormally activated by mutat...Genes that are a part of the normal regulation of cell division, but which after mutation contribute to cancer, are called proto-oncogenes. Once a proto-oncogene has been abnormally activated by mutation, it is called an oncogene. More than 100 genes have been defined as proto-oncogenes. These include genes at almost every step of the signaling pathways that normally induce cell to divide, including growth factors, receptors, signal transducers, and transcription factors.
- https://bio.libretexts.org/Courses/Norco_College/OpenStax_Biology_2e_for_Norco_College/10%3A_Cell_Reproduction/10.05%3A_Cancer_and_the_Cell_CycleCancer is the result of unchecked cell division caused by a breakdown of the mechanisms that regulate the cell cycle. The loss of control begins with a change in the DNA sequence of a gene that codes ...Cancer is the result of unchecked cell division caused by a breakdown of the mechanisms that regulate the cell cycle. The loss of control begins with a change in the DNA sequence of a gene that codes for one of the regulatory molecules. Faulty instructions lead to a protein that does not function as it should. Any disruption of the monitoring system can allow other mistakes to be passed on to the daughter cells. Each successive cell division will give rise to daughter cells with even more damage
- https://bio.libretexts.org/Bookshelves/Genetics/Online_Open_Genetics_(Nickle_and_Barrette-Ng)/13%3A_Cancer_Genetics/13.05%3A_OncogenesGenes that are a part of the normal regulation of cell division, but which after mutation contribute to cancer, are called proto-oncogenes. Once a proto-oncogene has been abnormally activated by mutat...Genes that are a part of the normal regulation of cell division, but which after mutation contribute to cancer, are called proto-oncogenes. Once a proto-oncogene has been abnormally activated by mutation, it is called an oncogene. More than 100 genes have been defined as proto-oncogenes. These include genes at almost every step of the signaling pathways that normally induce cell to divide, including growth factors, receptors, signal transducers, and transcription factors.
- https://bio.libretexts.org/Courses/Citrus_College/Citrus_College_General_Biology_Textbook/08%3A_Cell_Division_by_Mitosis/8.05%3A_Cancer_and_the_Cell_CycleCancer is the result of unchecked cell division caused by a breakdown of the mechanisms that regulate the cell cycle. The loss of control begins with a change in the DNA sequence of a gene that codes ...Cancer is the result of unchecked cell division caused by a breakdown of the mechanisms that regulate the cell cycle. The loss of control begins with a change in the DNA sequence of a gene that codes for one of the regulatory molecules. Faulty instructions lead to a protein that does not function as it should. Any disruption of the monitoring system can allow other mistakes to be passed on to the daughter cells. Each successive cell division will give rise to daughter cells with even more damage
- https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Principles_of_Biology/01%3A_Chapter_1/11%3A_Cell_Division_-_Binary_Fission_and_Mitosis/11.06%3A_Cancer_and_the_cell_cycleThe change in the cell that results from the misshaped protein may be minor: perhaps a slight delay in the binding of Cdk to cyclin or an Rb protein that detaches from its target DNA while still phosp...The change in the cell that results from the misshaped protein may be minor: perhaps a slight delay in the binding of Cdk to cyclin or an Rb protein that detaches from its target DNA while still phosphorylated. This result is detrimental to the cell and will likely prevent the cell from completing the cell cycle, which means that this cell cannot create daughter cells.
