This page provides an extensive overview of mechanotransduction and mechanosensitive (MS) ion channels, focusing on the Piezo1 and Piezo2 channels. It covers their structural and functional properties...This page provides an extensive overview of mechanotransduction and mechanosensitive (MS) ion channels, focusing on the Piezo1 and Piezo2 channels. It covers their structural and functional properties, including their three-bladed, propeller-shaped structures revealed by cryo-electron microscopy. The article discusses their roles in physiological processes, like erythrocyte volume regulation and their association with diseases due to mutations.