This article explores the regulation of glucose metabolism from a liver-centric perspective. The liver plays a vital role in maintaining glucose homeostasis through processes such as glycogenesis, gly...This article explores the regulation of glucose metabolism from a liver-centric perspective. The liver plays a vital role in maintaining glucose homeostasis through processes such as glycogenesis, glycogenolysis, glycolysis, and gluconeogenesis. Acute and chronic regulation of the enzymes involved is crucial for these processes. Transcription factors such as SREBP-1c and ChREBP are vital in controlling glucose metabolism, especially in glycolysis and gluconeogenesis paths.