For phagocytosis to occur, the surface of the microbe must be attached to the cytoplasmic membrane of the phagocyte through unenhanced or enhanced attachment. Following attachment, the microbe must be...For phagocytosis to occur, the surface of the microbe must be attached to the cytoplasmic membrane of the phagocyte through unenhanced or enhanced attachment. Following attachment, the microbe must be engulfed and placed on a membrane-bound vesicle called a phagosome. The phagosome then becomes acidified to provide the correct pH for killing by lysosomal enzymes. Lysosomes, containing digestive enzymes and microbicidal chemicals, fuse with the phagosome to destroy the engulfed microbe.
