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- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/Unit_IV_-_Special_Topics/28%3A_Biosignaling_-_Capstone_Volume_I/28.14%3A_Programmed_Cell_DeathThe page provides an in-depth exploration of programmed cell death, focusing particularly on apoptosis, its mechanisms, and its significance in health and disease. It distinguishes apoptosis from othe...The page provides an in-depth exploration of programmed cell death, focusing particularly on apoptosis, its mechanisms, and its significance in health and disease. It distinguishes apoptosis from other cell death types such as autophagy and necroptosis, outlining apoptosis's intrinsic and extrinsic pathways, including involved proteins like caspases and Bcl-2 family.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/01%3A_Unit_I-_Structure_and_Catalysis/05%3A_Protein_Function/5.04%3A_B._The_Innate_Immune_System_PAMPs_and_DAMPs_and_InflammationThis page discusses biochemistry learning goals, focusing on protein-ligand interactions and the immune system. Topics include immune response mechanisms, the role of signaling molecules like cGAMP, a...This page discusses biochemistry learning goals, focusing on protein-ligand interactions and the immune system. Topics include immune response mechanisms, the role of signaling molecules like cGAMP, and the importance of mRNA vaccines. It explains pathogen recognition via pattern recognition receptors, inflammasome formation involving proteins like ASC, and the activation of NLRP3 by PAMPS and DAMPS.
- https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/12%3A_Cancer/12.05%3A_BCL-2This page discusses BCL-2, a proto-oncogene on chromosome 18 involved in cancer by inhibiting apoptosis in B-cells. Its translocation with chromosome 14 (t(14;18)) results in Bcl-2 overexpression, aid...This page discusses BCL-2, a proto-oncogene on chromosome 18 involved in cancer by inhibiting apoptosis in B-cells. Its translocation with chromosome 14 (t(14;18)) results in Bcl-2 overexpression, aiding evasion of programmed cell death, thus promoting cancer. However, this translocation alone does not guarantee cancer, as many carriers remain healthy; other mutations, such as c-myc translocation, also play a role in B-cell malignancies.
- https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/01%3A_Unit_I-_Structure_and_Catalysis/05%3A_Protein_Function/5.04%3A_A._The_Immune_System_-_Antibodies_B-_cells_T-cell_receptors_and_T-cellsThis page provides an overview of the immune system's functionality, detailing the roles of both innate and adaptive immunity, particularly focusing on the mechanisms of B cells and T cells. Key eleme...This page provides an overview of the immune system's functionality, detailing the roles of both innate and adaptive immunity, particularly focusing on the mechanisms of B cells and T cells. Key elements include the structure and diversity of antibodies, significance of immunoglobulin domains, and the dynamics of antibody-antigen interactions.
- https://bio.libretexts.org/Bookshelves/Microbiology/Microbiology_(Kaiser)/Unit_6%3A_Adaptive_Immunity/14%3A_Cell-Mediated_Immunity/14.2%3A_Activating_Antigen-Specific_Cytotoxic_T-_LymphocytesCell-mediated immunity (CMI) is an immune response that does not involve antibodies but rather involves the activation of macrophages and NK-cells, the production of antigen-specific cytotoxic T-lymph...Cell-mediated immunity (CMI) is an immune response that does not involve antibodies but rather involves the activation of macrophages and NK-cells, the production of antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen. Cell-mediated immunity is directed primarily microbes that survive in phagocytes and microbes that infect non-phagocytic cells.
