This undergoes a conformational change (as we studied in the binding of dioxygen to hemoglobin) which leads to the expulsion of the bound ligand to the inside of the membrane (Lin). The equation will ...This undergoes a conformational change (as we studied in the binding of dioxygen to hemoglobin) which leads to the expulsion of the bound ligand to the inside of the membrane (Lin). The equation will show the rate of diffusion of a solute across a membrane from a region of high concentration to a region of low concentration (Δμ < 0) is a linear function of [ΔL] across the membrane.