This page explores the fundamentals of biochemistry with a focus on protein kinases, cellular signaling, and the kinome. It covers the diversity and structural features of kinases, how they are activa...This page explores the fundamentals of biochemistry with a focus on protein kinases, cellular signaling, and the kinome. It covers the diversity and structural features of kinases, how they are activated and regulated, including the detailed mechanisms of the kinome, kinases like Protein Kinase A, Protein Kinase C, and Akt, and their roles in signal transduction related to health and disease.
This page explains oncogenes, which are mutated genes that lead to cancer by causing uncontrolled cell division. Normal cells require growth factors to regulate mitosis through activated signaling pat...This page explains oncogenes, which are mutated genes that lead to cancer by causing uncontrolled cell division. Normal cells require growth factors to regulate mitosis through activated signaling pathways. Oncogenes can emerge from mutations in these pathways, heightening mutation rates. Additionally, genes that inhibit apoptosis or repair DNA can also become oncogenic. Unlike oncogenes, tumor-suppressor genes must have both alleles mutated to encourage cell division.
