Several lines of evidence, primarily from studies of recombination in yeast, required changes to the reciprocal exchange of DNA chains initiated at single-strand nicks. As just mentioned, one DNA dupl...Several lines of evidence, primarily from studies of recombination in yeast, required changes to the reciprocal exchange of DNA chains initiated at single-strand nicks. As just mentioned, one DNA duplex tended to be the donor of information and the other the recipient, in contrast to the equal exchange predicted by the original Holliday model. Also, in yeast, recombination could be initiated by double-strand breaks.
