The page discusses key concepts in biochemistry related to oxidative phosphorylation including the roles of AMP, ADP, and ATP in regulating metabolic pathways, the coupling of electron transport to pr...The page discusses key concepts in biochemistry related to oxidative phosphorylation including the roles of AMP, ADP, and ATP in regulating metabolic pathways, the coupling of electron transport to proton translocation, and the consequences of uncoupling. It emphasizes the integration of metabolic regulation across various pathways and how mitochondria communicate with the nucleus.
The page delves deeply into the regulation of key glycolytic enzymes: hexokinase, phosphofructokinase-1 (PFK-1), and pyruvate kinase. It discusses hexokinase's role in glucose trapping, variability du...The page delves deeply into the regulation of key glycolytic enzymes: hexokinase, phosphofructokinase-1 (PFK-1), and pyruvate kinase. It discusses hexokinase's role in glucose trapping, variability due to isozymes, and the influence of glucose-6-phosphate. The text outlines PFK-1's regulation by allosteric effectors like ATP and AMP, and gluconeogenesis vs. glycolysis control via fructose 2,6-bisphosphate.
