KP Procko Test

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Authored by KP. Last update: 5/4/23

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Introduction

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Figure \(\PageIndex{x}\) is an interactive iCn3D model of mammalian respirasome (5GPN)

Figure \(\PageIndex{6}\): [INSERT THE PDB TITLE as above (INSERT PDB CODE)]. Click the image for a popup or use this external link: [INSERT Lifelong short URL from File, Share Link in iCn3D)]. (Copyright; author via source). iCn3D model made by [YOUR NAME]

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Exercise \(\PageIndex{1}\)

What is the pKa of acetic acid?

Answer: 4.7

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MODEL

No inhibition (left) and Uncompetitive Inhibition (right)

Note that the Vcell reaction diagram is the same as for competitive and uncompetive inhibition. It doesn't explicitly show that the mixed inhibitor binds to both free and substrate-bound enzymes. Those interactions are addressed in the mathematical equations for mixed inhibition.

Initial values No Inhibition

Initial values With Uncompetitive Inhibitor

I is fixed for each simulation (as it is not converted to a product) but can be changed in the simulation below.

Select Load [model name] below

Select Start to begin the simulation.

Interactive Element

Select Plot to change Y axis min/max, then Reset and Play | Select Slider to change which constants are displayed | Select About for software information.

Move the sliders to change the constants and see changes in the displayed graph in real-time.

Time course model made using Virtual Cell (Vcell), The Center for Cell Analysis & Modeling, at UConn Health. Funded by NIH/NIGMS (R24 GM137787); Web simulation software (miniSidewinder) from Bartholomew Jardine and Herbert M. Sauro, University of Washington. Funded by NIH/NIGMS (RO1-GM123032-04)

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