Edmund - Structural Basis of Allostery, The Kinase Model

Last updated
Save as PDF

Page ID: 108153

\( \newcommand{\vecs}[1]{\overset { \scriptstyle \rightharpoonup} {\mathbf{#1}} } \) \( \newcommand{\vecd}[1]{\overset{-\!-\!\rightharpoonup}{\vphantom{a}\smash {#1}}} \)\(\newcommand{\id}{\mathrm{id}}\) \( \newcommand{\Span}{\mathrm{span}}\) \( \newcommand{\kernel}{\mathrm{null}\,}\) \( \newcommand{\range}{\mathrm{range}\,}\) \( \newcommand{\RealPart}{\mathrm{Re}}\) \( \newcommand{\ImaginaryPart}{\mathrm{Im}}\) \( \newcommand{\Argument}{\mathrm{Arg}}\) \( \newcommand{\norm}[1]{\| #1 \|}\) \( \newcommand{\inner}[2]{\langle #1, #2 \rangle}\) \( \newcommand{\Span}{\mathrm{span}}\) \(\newcommand{\id}{\mathrm{id}}\) \( \newcommand{\Span}{\mathrm{span}}\) \( \newcommand{\kernel}{\mathrm{null}\,}\) \( \newcommand{\range}{\mathrm{range}\,}\) \( \newcommand{\RealPart}{\mathrm{Re}}\) \( \newcommand{\ImaginaryPart}{\mathrm{Im}}\) \( \newcommand{\Argument}{\mathrm{Arg}}\) \( \newcommand{\norm}[1]{\| #1 \|}\) \( \newcommand{\inner}[2]{\langle #1, #2 \rangle}\) \( \newcommand{\Span}{\mathrm{span}}\)\(\newcommand{\AA}{\unicode[.8,0]{x212B}}\)

Authored by [YOUR NAME]. Last update: [FILL IN DATE]

Date of origin

Introduction

[ADD CONTENT]

New Heading

[ADD TEXT]

[ADD IMAGE] (saved to your computer and uploaded with picture icon from top menu bar or drag image file to location (required from svg image)

*Use the following under your picture:

Figure \(\PageIndex{x}\): [Add caption]

*Center Picture and Caption together using top menu bar

[ADD iCn3D Model]

Figure x is an interactive iCn3D model of [INSERT DESCRIPTIVE TEXT - often a modified version of the title from the actual PDB page (INSERT PDB CODE)]

Figure 66: [INSERT THE PDB TITLE as above (INSERT PDB CODE)]. Click the image for a popup or use this external link: https://structure.ncbi.nlm.nih.gov/i...KbCWx2etVfC2WA. (Copyright; author via source). iCn3D model made by [YOUR NAME]

[ADD MATHEMATIC GRAPH - REUSE]

*your text and graph

Figure \(\PageIndex{x}\): Add caption

[ADD VCELL/SBML SIMULATION - REUSE]

*your text before and after insert as needed

New Heading

Exercise \(\PageIndex{1}\)

What mutations to specific amino acid residues could be introduced to strengthen contacts between the upper and lower C-spine?

Answer

Mutations to create a greater extent of interaction or a stronger class of interaction are necessary to strengthen intramolecular contacts.

Example 1: Mutation of a small hydrophobic amino acid to a bulky hydrophobic or aromatic amino acid can be used to bridge the gap.

Example 2: Mutation to introduce a new hydrogen bond, salt bridge, or disulfide bond can be used to create a new link between these sections of the hydrophobic core.