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B10. Inhibitory Neurotransmitters

  • Page ID
    5598
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    The main inhibitory neurotransmitters are GABA (gamma-aminobutyric acid, which is made from Glu through decarboxylation of the α-C group) and glycine. The bind to transmiitter-gated chloride channels, which when open hyperpolarize the membrane. Benzodiazepines (like Valium and Librium - anti-anxiety and muscle-relaxing agents) and barbituates (like phenobarbital-hypnotics) bind at allosteric sites and potentiate the binding of each other and GABA.

    • GABA Biochemistry
    • iconexternal_link.gifOf Mice and Alcohol

    iconChime.gif Updated Chloride Channel Jmol14 (Java) | JSMol (HTML5)

    Figure: Mechanisms of Channel Gating

    gatingchannels.gif


    B10. Inhibitory Neurotransmitters is shared under a CC BY-NC-SA license and was authored, remixed, and/or curated by Henry Jakubowski.

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