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Biology LibreTexts

A. Amino Acids

Skills to Develop

  • state the charge on amino acid side chains using the Henderson Hasselbach equation and the approximate charge by inspection at any given pH
  • draw mechanisms and identify products for the reaction of nucleophilic side chains Lys and Cys with common chemical modification agents and extend this understanding to reactions of His.
  • draw mechanisms for disulfide exchange reactions for sulfhydryls using them and oxidation numbers to explain redox reactions of cysteine/cystine.

Thumbnail: Structure of human hemoglobin. The proteins α and β subunits are in red and blue, and the iron-containing heme groups in green. From PDB: 1GZX​. Image used with permission (GNU; Proteopedia Hemoglobin).