This page discusses research by Stephen W. Kuffler and Nobel laureates David H. Hubel and Torsten N. Wiesel, focusing on how ganglion and LGN cells react to light. Ganglion cells vary their firing rat...This page discusses research by Stephen W. Kuffler and Nobel laureates David H. Hubel and Torsten N. Wiesel, focusing on how ganglion and LGN cells react to light. Ganglion cells vary their firing rates based on light location on the retina, while LGN cells are affected by cortical connections. In the visual cortex, cells respond to light edges, suggesting a convergence of inputs that filters information to recognize features. Hubel and Wiesel's work culminated in a Nobel Prize in 1981.