This page discusses tumor suppressor genes, over 30 identified, crucial for DNA repair, apoptosis, and regulating cell division. Mutations, often loss-of-function, can be inherited or sporadic, with n...This page discusses tumor suppressor genes, over 30 identified, crucial for DNA repair, apoptosis, and regulating cell division. Mutations, often loss-of-function, can be inherited or sporadic, with notable examples like BRCA1 linked to breast cancer and p53 associated with tumor development and early-onset cancer. The page emphasizes the significant role these genes play in cancer risk, with sporadic mutations often influenced by environmental factors like UV exposure.
