This page describes the mechanisms of temperature sensing and thermoregulation in mammals, exploring the roles of different ion channels, particularly TRP and TREK channels, in detecting thermal stimu...This page describes the mechanisms of temperature sensing and thermoregulation in mammals, exploring the roles of different ion channels, particularly TRP and TREK channels, in detecting thermal stimuli. It delves into how these channels contribute to the sensation of heat, cold, and thermal pain, with TREK channels playing a key role in moderating thermoreceptor activity by hyperpolarizing cells and TRP channels depolarizing them to increase excitability.
