Infertility is the inability of a sexually mature adult to reproduce by natural means and is generally defined as the failure to achieve a successful pregnancy after at least one year of regular, unpr...Infertility is the inability of a sexually mature adult to reproduce by natural means and is generally defined as the failure to achieve a successful pregnancy after at least one year of regular, unprotected sexual intercourse. Primary infertility applies to cases in which an individual has never achieved a successful pregnancy. Secondary infertility applies to cases in which an individual has had at least one successful pregnancy, but fails to achieve another after trying for at least a year.