This artwork is entitled “Columbus and the Indian Maiden.” It was painted around 1875 by Constantino Brumidi, an Italian-American historical painter. It is a good image to represent the concept of Col...This artwork is entitled “Columbus and the Indian Maiden.” It was painted around 1875 by Constantino Brumidi, an Italian-American historical painter. It is a good image to represent the concept of Columbian exchange. This concept refers to the exchange of pathogens during initial contacts between Europeans and Native Americans, starting when Columbus arrived in the New World in 1492. One of those pathogens may have been the sexually transmitted bacterium that causes syphilis.