The kidneys play such vital roles in eliminating wastes and toxins and maintaining body-wide homeostasis that disorders of the kidneys may be life threatening. Gradual loss of normal kidney function c...The kidneys play such vital roles in eliminating wastes and toxins and maintaining body-wide homeostasis that disorders of the kidneys may be life threatening. Gradual loss of normal kidney function commonly occurs with a number of disorders, including diabetes mellitus and high blood pressure. Other disorders of the kidneys are caused by faulty genes that are inherited. Loss of kidney function may eventually progress to kidney failure.