Because these threats are associated with and/or exacerbated by human activities, they can be dynamic in their nature, develop rapidly, and persist at such large scales that wildlife populations have ...Because these threats are associated with and/or exacerbated by human activities, they can be dynamic in their nature, develop rapidly, and persist at such large scales that wildlife populations have little opportunity to adapt or move to safer areas. In this chapter, we explore how each of these threats impact wildlife and natural communities, and how they could push populations and species to extinction.