Oncogenes are generally dominant gain-of-function mutations of normal cellular genes called protooncogenes. These protooncogenes are themselves positive regulators of the cell cycle, but they are regu...Oncogenes are generally dominant gain-of-function mutations of normal cellular genes called protooncogenes. These protooncogenes are themselves positive regulators of the cell cycle, but they are regulated by other factors, either extracellular signals or intracellular mechanisms. Mutations that turn them into oncogenes specifically remove all or some of this regulation. They thus become overactive, and try to push the cell cycle forward leading to increased proliferation.
Oncogenes are generally dominant gain-of-function mutations of normal cellular genes called protooncogenes. These protooncogenes are themselves positive regulators of the cell cycle, but they are regu...Oncogenes are generally dominant gain-of-function mutations of normal cellular genes called protooncogenes. These protooncogenes are themselves positive regulators of the cell cycle, but they are regulated by other factors, either extracellular signals or intracellular mechanisms. Mutations that turn them into oncogenes specifically remove all or some of this regulation. They thus become overactive, and try to push the cell cycle forward leading to increased proliferation.
