The article discusses metabolic syndrome (MetS), emphasizing its increasing prevalence and complexities in diagnosis and treatment. Insulin resistance (IR), stemming from abdominal obesity, is highlig...The article discusses metabolic syndrome (MetS), emphasizing its increasing prevalence and complexities in diagnosis and treatment. Insulin resistance (IR), stemming from abdominal obesity, is highlighted as a significant factor. The paper underscores the roles of lipids, particularly fatty acids (FAs), in regulating insulin signaling and inflammation. It explores how imbalances in saturated and polyunsaturated fatty acids (PUFAs) affect glucose transport and inflammation.