This page examines mouse fibroblasts, highlighting the contrast between normal cells with contact inhibition and transformed 3T3 cells that lack this feature. It notes that while transformed cells can...This page examines mouse fibroblasts, highlighting the contrast between normal cells with contact inhibition and transformed 3T3 cells that lack this feature. It notes that while transformed cells can form tumors in test subjects despite not being cancerous, normal cells require specific nutrients and maintain a normal karyotype. In contrast, transformed and cancer cells can survive on simpler media and often exhibit abnormal karyotypes with irregular chromosome structures.
