The article discusses the significant role of gut microbiota-derived metabolites in metabolic disorders, which are increasing globally. These metabolites, from compounds like bile acids, short-chain f...The article discusses the significant role of gut microbiota-derived metabolites in metabolic disorders, which are increasing globally. These metabolites, from compounds like bile acids, short-chain fatty acids, and branched-chain amino acids, are central to understanding the pathogenesis of metabolic disorders such as obesity and diabetes. They have potential as biomarkers for early diagnosis and targets for therapeutic interventions.